Effect of Immune Checkpoint Inhibitors Plus Chemotherapy on Advanced Gastric Cancer Patients with Elevated Serum AFP or Hepatoid Adenocarcinoma

Figures & data

Figure 1 Histologic features of AFPGC and HAS. (A) HE staining of primary lesion of HAS. (B) HE staining of metastatic lesion of the same HAS patient as (A). (C) HE staining of AFPGC sample without typical HAS. (D) Immunohistochemical staining for AFP (negative) of AFPGC sample without typical HAS. (E) PD-L1 positive sample by immunohistochemical staining with SP263. (F) PD-L1 negative sample by immunohistochemical staining with SP263.

Figure 2 The distribution of AFPGC and HAS in enrolled patients. Nineteen patients were with AFP positive and 13 patients were diagnosed as HAS. Eleven HAS patients had high serum AFP.

Table 1 Baseline Characteristics of Patients

Variables		C-Group^a (N=14)	IC-Group^b (N=7)	P-value
Gender	Male	10	7	0.11
	Female	4	0
Age	≤60	5	1	0.31
	>60	9	6
ECOG	0	3	1	0.69
	1	11	6
HAS	yes	10	3	0.2
	no	4	4
Serum AFP (ng/mL)	>20	12	7	0.29
	≤20	2	0
Lauren classification	Intestinal	8	2	0.37
	Mixed	3	1
	Diffuse	3	4
Her-2 amplification	positive	3	0	0.19
	negative	11	7
Location of tumor	GEJ	5	1	0.31
	Stomach	9	6
Liver metastasis	yes	11	6	0.69
	no	3	1
CPS	<1	10	1	0.01
	≥1	4	6

Notes: ^aC-group, control group. ^bIC-group, immunotherapy group.

Table 2 Comparison of Objective Response Rates to Different Treatment Regimens

	Control Group (n=14)	Immunotherapy Group (n=7)
CR	0 (0)	1 (14.3%)
PR	3 (21.4%)	5 (71.4%)
SD	8 (57.1%)	0 (0)
PD	3 (21.4%)	1 (14.3%)

Figure 3 Comparison of progress-free survival (A) and overall survival (B) of AFPGC/HAS patients treated with chemotherapy and those receiving immunotherapy plus chemotherapy.

Abbreviations: C, chemotherapy; IC, immunotherapy plus chemotherapy.

Table 3 The Treatment of Immune Therapy Group and Evaluation of Effectiveness

No.	CPS	Efficacy	PFS (Month)
13	1	PR	19
14	<1	PR	6
15	1	CR	22
16	1	PR	NR^a (>21 months)
17	1	PR	NR^a (>25 months)
18	1	PR	NR^a (>16 months)
20	10	PD	1

Abbreviation: ^aNR, not reached