Lymphovascular Invasion as a Prognostic Factor in Non-Metastatic Adenocarcinoma of Esophagogastric Junction After Radical Surgery

Figures & data

Table 1 Baseline Characteristics of AEG Patients with or without LVI in Unweighted and Weighted Study Population

	Number of Patients (%) (N=224)	Unweighted Study Population, NO.%				Weighted Study Population,%
		LVI(+) (n=96)	LVI(-) (n=128)	P	SD	LVI(+) (n=96)	LVI(-) (n=128)	SD
Age(years), SD	62.8±9.6	61.1±9.4	64.0±9.5	0.022*	0.311	62.6±9.9	62.6±10.1	0.005
Sex
Male	166 (74.10)	72 (75.0)	94 (73.4)	0.792	0.036	71.1	73.2	0.068
Female	58 (25.90)	24 (25.0)	34 (26.6)			29.9	26.8
Tumor size (cm), SD	5.0±2.2	5.4±2.0	4.8±2.3	0.043*	0.277	4.9±1.9	5.1±2.5	0.091
Siewert type
I+II	136 (60.71)	49 (51.0)	87 (68.0)	0.010*	0.312	66.0	66.7	0.016
III	88 (39.29)	47 (49.0)	41 (32.0)			34.0	33.3
Differentiation
Moderate-high	110 (49.11)	36 (37.5)	74 (57.8)	0.008*	0.415	49.5	51.3
Low	114 (50.89)	60 (62.5)	54 (42.2)			50.5	48.7	0.037
pT stage
T1-2	41 (18.30)	9 (9.4)	32 (25.0)	0.003*	0.407	15.9	18.9	0.078
T3-4	183 (81.70)	87 (90.6)	96 (75.0)			84.1	81.1
pN stage
pN0-1	124 (55.36)	29 (30.2)	95 (74.2)	<0.001*	0.981	61.5	58.6	0.078
pN2-3	100 (44.63)	67 (69.8)	33 (25.8)			38.5	42.4
Her2
Negative	113 (50.45)	73 (76.0)	82 (64.1)	0.055	0.204	66.8	68.9	0.043
Positive	111 (49.55)	23 (24.0)	46 (35.9)			33.2	31.1
Ki67 (%), SD	59.6±22.7	59.5±22.5	58.7±23.0	0.967	0.007	58.8±22.3	60.0±23.1	0.052
LN ratio (%), SD	24.3±26.5	39.4±27.9	13.0±18.6	<0.001*	1.114	24.2±25.9	22.6±26.0	0.064
Surgical approach
Transabdominal	160 (71.4)	73 (76.0)	87 (68.0)	0.149	0.254	72.5	70.3	0.081
Transthoracic	57 (25.4)	22 (22.9)	35 (27.3)			23.4	26.4
Other	7 (3.1)	1 (1.1)	6 (4.7)			4.2	3.3
Neoadjuvant
Yes	23 (10.26)	11 (11.5)	12 (9.4)	0.611	0.068	9.5	10.0	0.016
No	201 (89.74)	85 (88.5)	116 (90.6)			90.5	90.0
Adjuvant
Yes	89 (39.73)	40 (41.7)	49 (38.3)	0.608	0.069	38.5	39.3	0.017
No	135 (61.27)	56 (59.3)	79 (61.7)			61.5	60.7

Notes: SD Standardized Difference; *P<0.05.

Table 2 Multivariable Logistic Regression Model Predicting with or Without LVI in the Unweighted Study Population

	OR	95% CI	P
Age	0.98	0.95–1.02	0.318
Siewert type
I+II	1	1
III	2.08	1.02–4.25	0.045*
Tumor size(cm)	1.13	0.96–1.36	0.134
pT stage
pT1-2	1	1
pT3-4	1.50	0.56–4.01	0.421
pN stage
pN0-1	1	1
pN2-3	2.25	1.05–4.82	0.038*
Differentiation
Moderate-high	1	1
Low	1.31	0.67–2.56	0.431
Her2
Negative	1	1
Positive	1.04	0.54–2.08	0.877
LN ratio (%)	1.04	1.02–1.06	<0.001*
Neoadjuvant	1.09	0.37–3.24	0.878

Note: *P<0.05.

Figure 1 Unadjusted and IPW-adjusted Kaplan–Meier analysis of disease-specific survival (DSS) and overall survival (OS) in patients with non-metastatic adenocarcinoma of esophagogastric junction after radical surgery. (A) Unadjusted K-M curves for DSS. (B) IPW-adjusted K-M curves for DSS. (C) Unadjusted K-M curves for OS. (D) IPW-adjusted K-M curves for OS.

Figure 2 Forrest plot depicting IPW-adjusted HRs of DSS in the group of LVI(+) versus LVI(-) according to baseline covariates.

Figure 3 Forrest plot depicting IPW-adjusted HRs of OS in the group of LVI(+) versus LVI(-) according to baseline covariates.