The Effect of Delayed Chemotherapy on the Decrease of CA125 in Epithelial Ovarian Cancer During Coronavirus Disease Pandemic in 2020

Figures & data

Table 1 The Characteristic of Patients and the Comparison of CA125 Half-Life (T1/2) in 2019 and 2020

Characteristic	2020	T1/2 in 2020	2019	T1/2 in 2019	P
Age(y)	56.03(36–69)	18.08±8.35	57.06(42–74)	17.95±8.68	0.904
Chemotherapy type*
NACT	8(25%)	23.05±5.03	7 (21.88%)	19.07±6.65	0.21
PCT	4(12.5%)	27.90±8.89	7 (21.88%)	19.17±6.72	0.09
MCT	20 (62.5%)	14.13±6.69	18 (56.25%)	17.04±10.19	0.30
FIGO stage
I	1 (3.13%)	21.9289	3 (9.38%)	14.11	/
II	10 (31.25%)	14.52±5.69	4 (12.5%)	23.86±12.37	0.69
III	18 (56.25%)	18.63±8.08	21 (65.63%)	16.85±6.65	0.45
IV	3 (9.38%)	25.40±15.06	4 (12.5%)	20.71±15.47	0.71
Histologic type&
High grade serous	24 (75%)	18.35±9.34	23 (71.88%)	17.22±8.23	0.66
Endometrioid	1 (3.13%)	16.505	4 (12.5%)	17.88	/
Clear cell	5 (15.62%)	15.25	1 (3.13%)	10.45	/
Other	2 (6.25%)	22.72	4 (12.5%)	24.12	/

Notes: *Chemotherapy type includes neoadjuvant chemotherapy (NACT), palliative chemotherapy (PCT) and maintenance chemotherapy (MCT), and histologic type including high grade serous adenocarcinoma, endometrial adenocarcinoma, clear cell carcinoma and unclassified adenocarcinoma.

Table 2 Comparison of CA125 T1/2 and CA125 Decrease Extent

Sub-Type (N)	T1/2	Ratio of DC Before	Ratio of DC After
The aim of chemotherapy: maintain chemotherapy or not
YES(19)	14.08±6.88	0.31±0.37	0.49±0.32
NO(13)	23.94±6.83	0.43±0.66	0.20±0.34
P	0.002	0.084	0.027
FIGO stage
I–II(10)	18.53±5.87	0.36±0.36	0.43±0.37
III–IV(22)	30.97±22.04	0.36±0.54	0.31±0.36
P	0.13	0.99	0.453
Histologic type
High serous(24)	26.13±15.77	0.32±0.52	0.32±0.35
Others(8)	33.03±30.10	0.49±0.40	0.38±0.40
P	0.41	0.397	0.719
Delayed chemotherapy occurred before or after CA125 turned negative
Before (19)	21.47±7.92	0.49±0.55	0.48±0.34
After(13)	17.53±9.25	0.17±0.33	0.04±0.19
P	0.001	0.001	0.001
The interval period more than 60 days
NO(15)	11.33±4.18	0.25±0.34	0.19±0.37
YES(17)	24.04±6.27	0.45±0.49	0.45±0.32
P	0.000	0.013	0.033
Delayed chemotherapy course, more than 2 times nor not.
2 times	24.01±6.87	0.39±0.61	0.57±0.31
More than 3 times	13.47±6.30	0.34±0.39	0.09±0.23
P	0.000	0.301	0.000

Notes: Chemotherapy type: YES means maintenance chemotherapy (MCT), neoadjuvant chemotherapy and palliative chemotherapy divided to NO. Histologic type including High grade serous adenocarcinoma and others, others including endometrial adenocarcinoma, clear cell carcinoma and unclassified adenocarcinoma.