Detection and Clinical Value of Circulating Tumor Cells as an Assisted Prognostic Marker in Colorectal Cancer Patients

Figures & data

Table 1 Preoperative Demographic Information and Pathological Features

	Total (n=149)	Colon Cancer (n=79)	Rectal Cancer (n=70)
Age (years)	63.19±11.80	63.38±11.74	62.97±11.94
Gender (M/F)	93/56	46/33	47/23
BMI (kg/m^2)	22.61±3.38	22.58±3.50	22.64±3.26
Stage I	42	23	19
Stage II	35	20	15
Stage III	58	26	32
Stage IV	14	10	4
CEA (ng/mL)	13.33±33.90	17.43±39.45	8.72±25.77
AFP (ng/mL)	3.51±2.03	3.52±2.09	2.49±1.97
CA125 (U/mL)	19.69±19.47	22.40±21.80	16.62±16.07
CA199 (U/mL)	47.51±114.82	48.37±113.52	46.54±117.08

Table 2 Comparison Between CTCNegative and CTCPositive Groups

	CTC+ (n=72)	CTC− (n=77)	P
Age (years)	63.22±12.10	63.16±12.10	0.973
Gender (M/F)	47/25	46/31	0.486
BMI (kg/m^2)	22.50±3.66	22.70±3.11	0.716
Stage I	8	34	0.000
Stage II	16	19
Stage III	36	22
Stage IV	12	2
CTC count/7.5 mL	7.75±3.26	1.94±0.92	0.000
CEA (ng/mL)	19.04±44.43	8.00±18.26	0.053
AFP (ng/mL)	3.95±2.01	3.10±1.97	0.010
CA125 (U/mL)	27.97±24.17	11.94±8.17	0.000
CA199 (U/mL)	62.15±117.85	33.82±110.92	0.133
Colon cancer	41	38	0.353
Rectal cancer	31	39
Left hemicolon cancer	39	46	0.492
Right hemicolon cancer	33	31

Table 3 Comparison Between CTC-Negative and CTC-Positive Groups in Different Tumor Stages in Patients with Colon Cancer and Rectal Cancer

	Colon Cancer (n=79)		P	Rectal Cancer (n=70)		P
	CTC− (0–3)	CTC+		CTC− (0–3)	CTC+
Stage I	18	5	0.001	16	3	0.013
Stage II	10	10		9	6
Stage III	9	17		13	19
Stage IV	1	9		1	3
T1	10	1	0.021	9	1	0.001
T2	8	9		12	3
T3	9	13		16	17
T4	11	18		2	10
N0	28	18	0.014	25	11	0.035
N1	9	16		10	9
N2	1	7		4	11
M0	37	33	0.018	38	28	0.203
M1	1	8		1	3

Table 4 Comparison Between CTC-Negative and CTC-Positive Groups in Different Stages in Patients with Left- and Right-Side CRC

	Left-Side CRC (n=85)		P	Right-Side CRC (n=64)		P
	CTC− (0–3)	CTC+		CTC− (0–3)	CTC+
Stage I	21	3	0.001	13	5	0.020
Stage II	10	8		9	8
Stage III	14	24		8	12
Stage IV	1	4		1	8
T1	11	1	0.000	8	1	0.059
T2	15	4		5	8
T3	18	18		7	12
T4	2	16		11	12
N0	31	14	0.005	22	15	0.077
N1	11	12		8	13
N2	4	13		1	5
M0	45	36	0.231	30	25	0.016
M1	1	3		1	8

Figure 1 Survival curve and risk curve in the CRC cohort. (A) Survival curve in the CRC cohort. (B) Risk curve in the CRC cohort.

Figure 2 Progression-free survival curve and risk curve of colorectal patients. (A) Progression-free survival curve of colorectal patients. (B) Risk curve of colorectal patients.

Figure 3 Survival curves and risk curves of colorectal patients in different stages. (A) Survival curve of colorectal patients in stage I. (B) Survival curve of colorectal patients in stage II. (C) Survival curve of colorectal patients in stage III. (D) Survival curve of colorectal patients in stage IV. (E) Risk curve of colorectal patients in stage I. (F) Risk curve of colorectal patients in stage II. (G) Risk curve of colorectal patients in stage III. (H) Risk curve of colorectal patients in stage IV.

Figure 4 Survival curves and risk curves of colorectal patients in different T stages. (A) Survival curve of colorectal patients in stage T2. (B) Survival curve of colorectal patients in stage T3. (C) Survival curve of colorectal patients in stage T4. (D) Risk curve of colorectal patients in stage T2. (E) Risk curve of colorectal patients in stage T3. (F) Risk curve of colorectal patients in stage T4.