RUNX2 as a promising therapeutic target for malignant tumors

Figures & data

Figure 1 Direct or indirect regulation of RUNX2 by miRNAs via the targeting of signaling pathways in BC. In BC, the miRNAs marked in red color play an oncogenic role, their expression levels are down-regulated; the miRNAs marked in black color act as tumor suppressor genes, their expression levels are up-regulated.

Figure 2 PI3K/AKT-dominated signaling pathway regulates RUNX2 in PCa.

Figure 3 Simulation diagram of RUNX2ʹ s regulation mechanism in malignant tumors. The dotted line indicates that further research is required.

Table 1 Regulation of RUNX2 Expression by miRNAs and lncRNAs in Osteosarcoma

No.	miRNA (s) or lncRNAs	Interaction Site	Role	Signaling Pathway	References
1	miR-150	Directly	Tumor Suppressor	Apoptosis proteins	[^Citation7]
2	LncRNA TUG1	Directly	Oncogene	-	[^Citation8]
3	miR-338-3p	Indirectly	Tumor Suppressor	MAPK	[^Citation9]
4	LncRNA SNHG20	Directly	Tumor Suppressor	Mitochondrial apoptosis	[^Citation10]
5	miR-340	Indirectly	Tumor Suppressor	Notch	[^Citation11]
6	miR-302B	Directly	Tumor Suppressor	-	[^Citation12^–^Citation14]
	miR-203
	miR-205

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