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Original Research

Adenocarcinoma of High-Grade Patterns Associated with Distinct Outcome of First-Line Chemotherapy or EGFR-TKIs in Patients of Relapsed Lung Cancer

, , , , , , , , , , , , , , & show all
Pages 3981-3990 | Published online: 17 May 2021

Figures & data

Table 1 Baseline Characteristics of the Patients

Figure 1 Distribution of histological subtypes in relapsed patients.

Figure 1 Distribution of histological subtypes in relapsed patients.

Figure 2 Flowchart of the patient selection process.

Figure 2 Flowchart of the patient selection process.

Table 2 Impact of Predictive Factors on Chemotherapy in Univariate and Multivariate Analyses (n = 108)

Figure 3 Kaplan-Meier survival curves for patients in different cohorts. (A) Progression-free survival (PFS) of first-line chemotherapy in epidermal growth factor receptor (EGFR) wild-type patients with high-grade patterns and in control subjects; (B) overall survival (OS) of first-line chemotherapy in EGFR wild-type patients with high-grade patterns and control cohorts; (C) PFS curves of first-line EGFR-tyrosine kinase inhibitor (TKI) treatment in EGFR+ patients with high-grade patterns and control cohorts; (D) OS curves of first-line EGFR-TKI treatment in EGFR+ patients with high-grade patterns and control cohorts.

Figure 3 Kaplan-Meier survival curves for patients in different cohorts. (A) Progression-free survival (PFS) of first-line chemotherapy in epidermal growth factor receptor (EGFR) wild-type patients with high-grade patterns and in control subjects; (B) overall survival (OS) of first-line chemotherapy in EGFR wild-type patients with high-grade patterns and control cohorts; (C) PFS curves of first-line EGFR-tyrosine kinase inhibitor (TKI) treatment in EGFR+ patients with high-grade patterns and control cohorts; (D) OS curves of first-line EGFR-TKI treatment in EGFR+ patients with high-grade patterns and control cohorts.

Figure 4 Response to different therapies in different cohorts. (A) Response to first-line chemotherapy in high-grade patterns and control cohorts. (B) Response to first-generation tyrosine kinase inhibitors (TKIs) in high-grade patterns and control cohorts.

Abbreviations: ORR, objective response rate; PR, partial response; SD, stable disease; PD, progressive disease.
Figure 4 Response to different therapies in different cohorts. (A) Response to first-line chemotherapy in high-grade patterns and control cohorts. (B) Response to first-generation tyrosine kinase inhibitors (TKIs) in high-grade patterns and control cohorts.

Table 3 Impact of Predictive Factors on EGFR-TKIs in Univariate and Multivariate Analyses (n = 131)