Esophagogastric Cancer After Sleeve Gastrectomy: A Systematic Review of Case Reports

Figures & data

Table 1 The Basic Condition of the Patient Before Sleeve Gastrectomy

Author (Year)	Nation	Age	Sex	BMI Before SG	Previous UGIE	Endoscopic Findings	HP Infection	Smoking	Comorbidity
Scheepers 2011^Citation13	Netherlands	57	F	51.8	Not	–	–	Yes	OSA, COPD, probably GERD and degenerative joint disease
Angrisani 2014^Citation14	Italy	51	F	61	Yes	Significant infiltration of plasma cells in the lamina propria	HP-	-	GERD, OSA, hypertension, dyslipidemia
Erim 2015^Citation15	USA	52	F	-	Yes	-	-	-	T2DM, hyperlipidemia, hypertension
Masrur 2016^Citation16	USA	44	F	38.2	Not	-	HP-	Yes	OSA, Hypertension, T1DM, hyperlipidemia
Sohn 2017^Citation17	New Zealand	44	F	42	Not	-	HP-	Not	OSA, hyperlipidemia
Vladimirov 2017^Citation18	Germany	47	F	47.7	Yes	Small hiatal hernia and erosive gastritis.	HP-	Yes	COPD
Wright 2017^Citation19	Argentina	48	M	48.5	Yes	Absence of reflux or hiatal hernia, no esophagitis or Barrett’s esophagus	HP-	-	OSA, hypertension, dyslipidemia, insulin resistance
EI Khoury 2018^Citation20	France	55	F	42	Yes	Barrett’s esophagus	-	Not	T2DM, hypertension, dyslipidemia, arthritis
Sista 2018^Citation21	Italy	45	M	42.7	-		-	-	-
Seki 2018^Citation22	Japan	64	F	35.3	Yes	Chronic atrophic gastritis	HP-	Not	T2DM
Yamashita 2019^Citation23	Singapore	42	F	35.8	Not	-	HP-	Not	GERD, chronic gastritis
Güzel 2020^Citation24	Cyprus	60	M	38.5	-	-	-	-	T2DM
Muamar 2020^Citation25	Jordan	26	F	52	Yes	-	HP-	Not	-
Aljarboo 2020^Citation26	Saudi Arabia	58	F	52	-	-	Hp+	Not	GERD, hypertension, hypothyroidism, bronchial asthma, rheumatoid arthritis
Genco 2020^Citation27	Italy	54	M	43.1	Yes	No abnormal finding	-	Yes	Hypertension, dyslipidemia, T2DM
Genco 2020^Citation27	Italy	21	M	75.6	Yes	No abnormal finding	-	Not	OSA
Genco 2020^Citation27	Italy	39	M	46.3	Yes	No abnormal finding	-	Yes	Hypertension

Abbreviations: UGIE, upper gastrointestinal endoscopy; HP, Helicobacter pylori; OSA, obstructive sleep apnea; COPD, chronic obstructive pulmonary disease; GERD, gastroesophageal reflux disease; T1DM or T2DM, type 1 or type 2 diabetes mellitus.

Table 2 Demographic, Clinical, and Operative Data of the Patient Population

Author (Year)	BMI at Diagnosis of Tumor	Years After SG (Months)	Symptom Duration(Months)	Tumor Location	Tumor Histology	Tumor Stage	Type of Treatment	Follow-Up, Mo
Scheepers 2011^Citation13	-	4	3	Distal esophagus	Adenocarcinoma	T2N1Mx	Chemoradiotherapy	8mo, disease–free survival
Angrisani 2014^Citation14	47	48	-	Body and antrum	Signet-ring cell adenocarcinoma	pT4aN1	Total gastrectomy, Roux-en-Y reconstruction	8mo, disease–free survival
Erim 2015^Citation15	-	48	-	Gastric cardia	Carcinoid	-	Submucosal endoscopic dissection	-
Masrur 2016^Citation16	31	8	9	Gastroesophageal junction	Adenocarcinoma	pT4bN3a	Robot-assisted extended total gastrectomy, Roux-en-Y reconstruction	8mo, disease–free survival
Sohn 2017^Citation17	23.8	24	-	Gastroesophageal junction	Adenocarcinoma	T3N0M0	Chemotherapy + esophagogastrectomy	-
Vladimirov 2017^Citation18	-	48	48	Antrum	Adenocarcinoma	pT1bpN0	Total gastrectomy, Roux-en-Y reconstruction	24mo, disease–free survival
Wright 2017^Citation19	-	60	33	Distal esophagus	Adenocarcinoma	-	Chemoradiotherapy	-
EI Khoury 2018^Citation20	-	36	Several	Distal esophagus	Adenocarcinoma	PT1NO	Endoscopic mucosectomy	-
Sista 2018^Citation21	-	42	-	Pylorus	Carcinoid	-	Endoscopic radical resection	36mo, disease–free survival
Seki 2018^Citation22	≤29.3	12	-	Antrum	Adenocarcinoma	pT1a	Endoscopic submucosal resection	-
Yamashita 2019^Citation23	-	96	-	Body and antrum	Signet-ring cell adenocarcinoma	pT4aN0	Total gastrectomy with lymphadenectomy and omentectomy	12mo, disease–free survival
Güzel 2020^Citation24	28	36	2	Body	Signet-ring cell adenocarcinoma	-	Total gastrectomy and D2 lymph node dissection	-
Muamar 2020^Citation25	32.7	63	60	Antrum	Signet-ring cell adenocarcinoma	ypT1N0	Neoadjuvant chemotherapy+ total gastrectomy+ chemotherapy	3mo, disease–free survival
Aljarboo 2020^Citation26	42	48	4	Gastroesophageal junction	Adenocarcinoma	pT2N1M0	Neoadjuvant chemotherapy +distal esophagectomy and total gastrectomy with Roux-en-Y esophagojejunostomy	-
Genco 2020^Citation27	33.4	24	12	Distal esophagus	Adenocarcinoma	pT2N1M1	Open subtotal esophagectomy with colonic interposition+ adjuvant chemotherapy	5mo, Death
Genco 2020^Citation27	70.6	22	-	Gastric cardia	Adenocarcinoma	pT3N0M0	Open subtotal esophagectomy with Roux-en-Y esophagojejunostomy= adjuvant chemotherapy	6mo, disease–free survival
Genco 2020^Citation27	25.0	36		Gastroesophageal junction	Adenocarcinoma	cT3N1M1	-	Death during completion of diagnostic assessment

Figure 1 PRISMA flow diagram for selection of studies.

Table 3 Patients’ Symptoms

Symptoms	n (%)
Food intolerance/dyspepsia	7 (50.0%)
Vomiting/Nausea/Regurgitation	5 (35.7%)
Abdominal/epigastric pain	5 (35.7%)
Dysphagia	4 (28.6%)
Iron deficiency/Anemia	3 (21.4%)
Asthenia	2 (14.3%)
Heartburn	2 (14.3%)
Bloating	1 (7.1%)
Back pain	1 (7.1%)

Note: Data are reported as numbers and percentages (%).

Scheepers AF, Schoon EJ, Nienhuijs SW. Esophageal carcinoma after sleeve gastrectomy. Surg Obes Relat Dis. 2011;7(4):e11–e12. doi:10.1016/j.soard.2010.09.01921126926

 PubMedGoogle Scholar

Angrisani L, Santonicola A, Iovino P. Gastric cancer: a de novo diagnosis after laparoscopic sleeve gastrectomy. Surg Obes Relat Dis. 2014;10(1):186–187. doi:10.1016/j.soard.2013.09.00924355319

 PubMed Web of Science ®Google Scholar

Erim T, Colak Y, Szomstein S. Gastric carcinoid tumor after laparoscopic sleeve gastrectomy. Surg Obes Relat Dis. 2015;11(6):e51–e52. doi:10.1016/j.soard.2015.06.01626507937

 PubMed Web of Science ®Google Scholar

Masrur M, Elli E, Gonzalez-Ciccarelli LF, Giulianotti PC. De novo gastric adenocarcinoma 1 year after sleeve gastrectomy in a transplant patient. Int J Surg Case Rep. 2016;20:10–13. doi:10.1016/j.ijscr.2015.12.04526774417

 PubMedGoogle Scholar

Sohn S, Fischer J, Booth M. Adenocarcinoma of the gastro-oesophageal junction after sleeve gastrectomy: a case report. ANZ J Surg. 2017;87(10):E163–e164. doi:10.1111/ans.1306425827159

 PubMed Web of Science ®Google Scholar

Vladimirov M, Hesse U, Stein HJ. Gastric carcinoma after sleeve gastrectomy for obesity. Surg Obes Relat Dis. 2017;13(8):1459–1461. doi:10.1016/j.soard.2017.04.02028619681

 PubMed Web of Science ®Google Scholar

Wright FG, Duro A, Medici JR, et al. Esophageal adenocarcinoma five years after laparoscopic sleeve gastrectomy. A case report. Int J Surg Case Rep. 2017;32:47–50. doi:10.1016/j.ijscr.2017.01.05428235650

 PubMed Web of Science ®Google Scholar

El Khoury L, Benvenga R, Romero R, et al. Esophageal adenocarcinoma in Barrett’s esophagus after sleeve gastrectomy: case report and literature review. Int J Surg Case Rep. 2018;52:132–136. doi:10.1016/j.ijscr.2018.10.01530343262

 PubMed Web of Science ®Google Scholar

Sista F, Abruzzese V, Carandina S, et al. Which is the correlation between carcinoid tumor and laparoscopic sleeve gastrectomy? A case series and literature review. Ann Med Surg. 2018;36:252–255. doi:10.1016/j.amsu.2018.09.010

 PubMed Web of Science ®Google Scholar

Seki Y, Kasama K, Tanaka T, et al. Early gastric cancer successfully treated by endoscopic submucosal resection 1 year after laparoscopic sleeve gastrectomy with duodenal-jejunal bypass. Asian J Endosc Surg. 2019;12(3):357–361. doi:10.1111/ases.1263030015399

 PubMed Web of Science ®Google Scholar

Yamashita T, Tan J, Lim E, et al. A case of gastric cancer after sleeve gastrectomy. Asian J Endosc Surg. 2020;13(4):586–591. doi:10.1111/ases.1277731823477

 PubMed Web of Science ®Google Scholar

Guzel K. A gastric cancer following sleeve gastrectomy with transit bipartition surgery. Indian J Surg. 2020. doi:10.1007/s12262-020-02291-y

 Web of Science ®Google Scholar

Muamar AS, Ammori BJ. Non-cardia gastric adenocarcinoma more than 5 years after laparoscopic sleeve gastrectomy: a case report and literature review. Asian J Endosc Surg. 2020. doi:10.1111/ases.12850

 PubMed Web of Science ®Google Scholar

Aljarboo A, Alghamdi F, Alzahrani A, Ali B. A case of gastroesophageal cancer after laparoscopic sleeve gastrectomy. J Gastr Surg. 2020;2(4):127–129.

 Google Scholar

Genco A, Castagneto-Gissey L, Lorenzo M, et al. Esophageal adenocarcinoma after sleeve gastrectomy: actual or potential threat? Italian series and literature review. Surg Obes Relat Dis. 2020. doi:10.1016/j.soard.2020.11.023

 Web of Science ®Google Scholar