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Review

The Functional Hallmarks of Cancer Predisposition Genes

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Pages 4351-4357 | Published online: 01 Jun 2021

Figures & data

Figure 1 Proposed model of cancer genetic predisposition through a micro-evolutionary perspective. Pathogenic germline variants of cancer predisposition genes (CPGs) affecting a host of cellular pathways including DNA repair, oncogenic signaling, metabolism, and cell cycle, among others, can predispose to human cancer on a spectrum from increasing mutation acquisition and cellular proliferation. While the cancer predisposition field has traditionally focused on dysfunctional DNA repair as a mechanism of carcinogenesis largely through increasing clonal diversity, we propose that additional pathways that might also confer clonal fitness advantages that are important to consider in a cancer predisposition model.

Figure 1 Proposed model of cancer genetic predisposition through a micro-evolutionary perspective. Pathogenic germline variants of cancer predisposition genes (CPGs) affecting a host of cellular pathways including DNA repair, oncogenic signaling, metabolism, and cell cycle, among others, can predispose to human cancer on a spectrum from increasing mutation acquisition and cellular proliferation. While the cancer predisposition field has traditionally focused on dysfunctional DNA repair as a mechanism of carcinogenesis largely through increasing clonal diversity, we propose that additional pathways that might also confer clonal fitness advantages that are important to consider in a cancer predisposition model.