Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives

Figures & data

Table 1 The Regulatory Mechanisms of lncRNAs in Aerobic Glycolysis

LncRNA	Expression	Cancer Type	Functions and Targets	Reference
CRNDE	Up	CRC	Upregulates GLUT4; increases glucose uptake	[^Citation49]
p23154	Up	OSCC	Upregulates GLUT1; enhances glycolysis; promotes metastasis and invasion	[^Citation50]
NEF	Down	NSCLC	Downregulates GLUT1; reduces glucose uptake and cell proliferation	[^Citation51]
MORT	Down	Prostate carcinoma	Downregulates GLUT1; promotes cell proliferation and glucose uptake	[^Citation52]
DBH-AS1	Up	Melanoma	CeRNA for miR-223-3p; increases GLUT1 expression; facilitates cell proliferation and metastasis	[^Citation55]
MACC1-AS1	Up	Gastric cancer	Promotes the translocation of GLUT1 to the cell membrane; enhances glycolysis and glucose uptake; promotes cancer progression	[^Citation57]
SLC16A1-AS1	Up	Bladder cancer	Binds with E2F1 to co-activate the MCT1; promotes aerobic glycolysis and tumorigenesis	[^Citation59]
HOTAIR	Up	Pancreatic adenocarcinoma	Activates HK2 at the transcriptional level; promotes cell proliferation and glycolysis	[^Citation65]
NRCP	Up	Ovarian cancer	Acts as an intermediate binding partner between RNA polymerase II and STAT1; increases glucose-6-phosphate isomerase, ALDOA and ALDOC expression; promotes glycolysis and tumor growth	[^Citation66]
IGFBP4-1	Up	NSCLC	Increases HK2 and LDHA expression at the transcriptional level; promotes glycolysis and tumor growth	[^Citation67]
SNHG6	Up	CRC	Promotes the proportion of PKM2/PKM1 through alternative splicing; promotes glycolysis and tumor growth	[^Citation70]
HOXB-AS3	Down	Colon cancer	Encodes a peptide that inhibits the expression of PKM2; inhibits glycolysis and tumor growth	[^Citation72]
DLX6-AS1	Up	Gastric cancer	CeRNA for miR-4290; increases PDK1 expression; promotes glycolysis and cancer progression	[^Citation73]
KCNQ1OT1	Up	Osteosarcoma	CeRNA for miR-34c-5p; increases ALDOA expression; promotes glycolysis and tumor growth	[^Citation74]
WFDC21P	Down	HCC	Transcriptionally activated by Nur77; inhibits the catalytic activity of PFKP and blocks the nuclear localization of PKM2 to suppress its transcriptional activity; inhibits glycolysis and hepatocarcinogenesis	[^Citation75,Citation76]
HULC	Up	HCC	Enhances the phosphorylation of the LDHA and PKM2; promotes glycolysis and cell proliferation	[^Citation77]
YIYA	Up	Breast cancer	Promotes the CDK6 dependent phosphorylation of PFKFB3; promotes glycolysis and tumor growth	[^Citation78]
FEZF1-AS1	Up	CRC	Inhibits the ubiquitin-mediated degradation of PKM2; promotes glycolysis and cancer metastasis	[^Citation80]
LINC00470	Up	Glioblastoma	Promotes the phosphorylation of AKT; inhibits HK1 ubiquitinate-mediated degradation; enhances aerobic glycolysis and carcinogenesis	[^Citation81]
HIFAL	Up	Breast cancer	Recruits the PHD3 to hydroxylate PKM2; drives the nuclear translocation of hydroxyl-PKM2/PHD3 complex by hnRNPF; promotes aerobic glycolysis and tumor growth	[^Citation82]
PCED1B-AS1	Up	Glioblastoma	Promotes the translation of HIF-1α mRNA; facilitates glycolysis and carcinogenesis	[^Citation85]
MIR210HG	Up	TNBC	Increases the HIF-1α protein level; enhances the expression of LDHA, PKM2 and GLUT1; promotes glycolysis and tumor growth	[^Citation86]
LincRNA-p21	Up	Various cancers	Inhibits the degradation of HIF-1α; activates GLUT1 and LDHA; promotes Warburg effect	[^Citation88]
LINK-A	Up	TNBC	Prevents the degradation of HIF-1α; recruites LRRK2 to phosphorylate HIF-1α, which promotes Warburg effect	[^Citation89]
PCGEM1	Up	Prostate cancer	Promotes the transcriptional activation of c-Myc on metabolic genes through enhancing histone H3 and H4 acetylation	[^Citation92]
GLCC1	Up	CRC	Strengthens the interaction between HSP90 and USP22, which stabilizes c-Myc; transcriptionally activates LDHA; promotes glycolysis and cell proliferation	[^Citation93]
IDH1-AS1	Down	Various cancers	c-Myc stabilizes HIF-1α through IDH1-AS1/IDH1-αKG/ROS-HIF1α pathway, which promotes aerobic glycolysis	[^Citation95]
LINC00184	Up	Esophageal cancer	Recruits DNMT1 to the promoter of PTEN to inhibiting its expression; promotes glycolysis	[^Citation101]
ANRIL	Up	Nasopharyngeal carcinoma	Activates AKT/mTOR signaling to upregulate GLUT-1, resulting in enhanced glycolysis	[^Citation102]
UCA1	Up	Bladde cancer	Activates mTOR to upregulate HK2 via both activating STAT3 and inhibiting miR-143; facilitates aerobic glycolysis	[^Citation103]
LINC01554	Down	HCC	Inactivates AKT/mTOR signaling pathway; abolishs tumorigenicity and aerobic glycolysis	[^Citation104]
XIST	Up	Glioblastoma	CeRNA for miR-126; promotes glycolysis via IRS1/PI3K/Akt/GLUT pathway	[^Citation106]
LINC00473	Up	NSCLC	Induced by LKB1 loss; interacts with NONO; promotes tumor growth	[^Citation115,Citation116]
NBR2	Down	Various cancers	Potentiates AMPK activation; inhibits GLUT-1 expression; inhibits EMT and glycolysis.	[^Citation117,Citation118]
MALAT1	Up	HCC	Inhibits p53 pathway; promotes tumor growth	[^Citation123]
MEG3	Down	Breast cancer	Promotes p53 pathway; inhibits tumor growth	[^Citation124,Citation125]
SNHG9	Up	Glioblastoma	Promotes glycolytic metabolism and cell growth by downregulating miR-199a-5p and upregulating Wnt2	[^Citation128]
SNHG3	Up	Laryngeal squamous cell carcinoma	Promotes glycolysis and tumor growth by abolishing Wnt pathway via modulating the miR-340-5p/ YAP1 axis	[^Citation129]
LINC00857	Up	Ovarian cancer	Promotes ovarian cancer glycolysis through inactivating Hippo pathway via competitively binding to miR-486-5p	[^Citation131]
BCAR4	Up	Breast cancer	YAP enhances its expression; coordinates Hedgehog pathway to promote the transcriptions of HK2 and PFKFB3	[^Citation132]
UCA1	Up	Breast cancer	TGF-β-Hippo signaling upregulates its expression; activates AKT and STAT3 to promote glycolysis	[^Citation134]
LINC01420	Up	Pancreatic cancer	Promotes RAS signaling; promotes cancer progression	[^Citation137]
LncRNA-ATB	Up	Bladder cancer	Promotes RAS signaling; enhances cell proliferation and invasion	[^Citation138]
H19	Up	Colon cancer	Promotes RAS/MAPK signaling; promotes colon cancer progression	[^Citation139]

Figure 1 LncRNAs regulate cancer glycolysis by modulating metabolic enzymes and transporters.

Figure 2 LncRNAs regulate cancer glycolysis by modulating metabolic pathways.

Table 2 The Deregulated Mechanisms of lncRNAs in Aerobic Glycolysis

LncRNA	Expression	Regulatory Molecules	Regulatory Mechanisms	Reference
LINC00261	Down	EZH2	EZH2 and DNA methylation inhibit its expression	[^Citation140]
SNHG16	Up	TFAP2A	TFAP2A activates its transcription	[^Citation142]
LINC01123	Up	c-Myc	c-Myc activates its transcription	[^Citation143]
IDH1-AS1	Down	c-Myc	c-Myc inhibits its transcription	[^Citation95]
AGPG	Up	p53	p53 inhibits transcription	[^Citation144]
EPB41L4A-AS1	Down	p53	p53 activates its transcription	[^Citation145]
ENO1-IT1	Up	SP1	F. nucleatum recruit SP1 to activate its transcription	[^Citation147]
AC020978	Up	HIF-1α	HIF-1α activates its transcription	[^Citation148]
HIFAL	Up	HIF-1α	HIF-1α activates its transcription	[^Citation82]
linc-p21	Up	HIF-1α	HIF-1α activates its transcription	[^Citation88]

Figure 3 The deregulated mechanisms of lncRNAs in cancer glycolysis.

Ellis BC, Graham LD, Molloy PL. CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism. Biochim Biophys Acta. 2014;1843(2):372–386. doi:10.1016/j.bbamcr.2013.10.01624184209

 PubMed Web of Science ®Google Scholar

Wang Y, Zhang X, Wang Z, et al. LncRNA-p23154 promotes the invasion-metastasis potential of oral squamous cell carcinoma by regulating Glut1-mediated glycolysis. Cancer Lett. 2018;434:172–183. doi:10.1016/j.canlet.2018.07.01630026052

 PubMed Web of Science ®Google Scholar

Chang L, Xu W, Zhang Y, Gong F. Long non-coding RNA-NEF targets glucose transportation to inhibit the proliferation of non-small-cell lung cancer cells. Oncol Lett. 2019;17(3):2795–2801. doi:10.3892/ol.2019.991930854054

 PubMed Web of Science ®Google Scholar

Shi Z, Guo F, Jia D, et al. Long non-coding RNA mortal obligate RNA transcript suppresses tumor cell proliferation in prostate carcinoma by inhibiting glucose uptake. Oncol Lett. 2019;18(4):3787–3791. doi:10.3892/ol.2019.1071131516590

 PubMed Web of Science ®Google Scholar

Chen XX, Zhang N, Fu XF, Jiang Y, Wang MY. LncRNA DBH-AS1 facilitates the tumorigenesis of melanoma by targeting miR-233-3p via IGF-1R/Akt signaling. Eur Rev Med Pharmacol Sci. 2020;24(14):7698–7708. doi:10.26355/eurrev_202007_2227232744696

 PubMed Web of Science ®Google Scholar

Zhao Y, Liu Y, Lin L, et al. The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1. Mol Cancer. 2018;17(1):69. doi:10.1186/s12943-018-0820-229510730

 PubMed Web of Science ®Google Scholar

Logotheti S, Marquardt S, Gupta SK, et al. LncRNA-SLC16A1-AS1 induces metabolic reprogramming during bladder cancer progression as target and co-activator of E2F1. Theranostics. 2020;10(21):9620–9643. doi:10.7150/thno.4417632863950

 PubMed Web of Science ®Google Scholar

Ma Y, Hu M, Zhou L, et al. Long non-coding RNA HOTAIR promotes cancer cell energy metabolism in pancreatic adenocarcinoma by upregulating hexokinase-2. Oncol Lett. 2019;18(3):2212–2219. doi:10.3892/ol.2019.1055131452722

 PubMed Web of Science ®Google Scholar

Rupaimoole R, Lee J, Haemmerle M, et al. Long noncoding RNA ceruloplasmin promotes cancer growth by altering glycolysis. Cell Rep. 2015;13(11):2395–2402. doi:10.1016/j.celrep.2015.11.04726686630

 PubMed Web of Science ®Google Scholar

Yang B, Zhang L, Cao Y, et al. Overexpression of lncRNA IGFBP4-1 reprograms energy metabolism to promote lung cancer progression. Mol Cancer. 2017;16(1):154. doi:10.1186/s12943-017-0722-828946875

 PubMed Web of Science ®Google Scholar

Lan Z, Yao X, Sun K, Li A, Liu S, Wang X. The interaction between lncRNA SNHG6 and hnRNPA1 contributes to the growth of colorectal cancer by enhancing aerobic glycolysis through the regulation of alternative splicing of PKM. Front Oncol. 2020;10:363. doi:10.3389/fonc.2020.0036332296635

 PubMed Web of Science ®Google Scholar

Huang JZ, Chen M, Chen D, et al. A peptide encoded by a putative lncRNA HOXB-AS3 suppresses colon cancer growth. Mol Cell. 2017;68(1):171–84.e6. doi:10.1016/j.molcel.2017.09.01528985503

 PubMed Web of Science ®Google Scholar

Qian Y, Song W, Wu X, et al. DLX6 antisense RNA 1 modulates glucose metabolism and cell growth in gastric cancer by targeting microRNA-4290. Dig Dis Sci. 2021;66(2):460–473. doi:10.1007/s10620-020-06223-432239379

 PubMed Web of Science ®Google Scholar

Shen Y, Xu J, Pan X, et al. LncRNA KCNQ1OT1 sponges miR-34c-5p to promote osteosarcoma growth via ALDOA enhanced aerobic glycolysis. Cell Death Dis. 2020;11(4):278. doi:10.1038/s41419-020-2485-132332718

 PubMed Web of Science ®Google Scholar

Yang W, Zheng Y, Xia Y, et al. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol. 2012;14(12):1295–1304. doi:10.1038/ncb262923178880

 PubMed Web of Science ®Google Scholar

Guan YF, Huang QL, Ai YL, et al. Nur77-activated lncRNA WFDC21P attenuates hepatocarcinogenesis via modulating glycolysis. Oncogene. 2020;39(11):2408–2423. doi:10.1038/s41388-020-1158-y31959898

 PubMed Web of Science ®Google Scholar

Wang C, Li Y, Yan S, et al. Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2. Nat Commun. 2020;11(1):3162. doi:10.1038/s41467-020-16966-332572027

 PubMed Web of Science ®Google Scholar

Xing Z, Zhang Y, Liang K, et al. Expression of long noncoding RNA YIYA promotes glycolysis in breast cancer. Cancer Res. 2018;78(16):4524–4532. doi:10.1158/0008-5472.Can-17-038529967256

 PubMed Web of Science ®Google Scholar

Bian Z, Zhang J, Li M, et al. LncRNA-FEZF1-AS1 promotes tumor proliferation and metastasis in colorectal cancer by regulating PKM2 signaling. Clin Cancer Res. 2018;24(19):4808–4819. doi:10.1158/1078-0432.Ccr-17-296729914894

 PubMed Web of Science ®Google Scholar

Liu C, Zhang Y, She X, et al. A cytoplasmic long noncoding RNA LINC00470 as a new AKT activator to mediate glioblastoma cell autophagy. J Hematol Oncol. 2018;11(1):77. doi:10.1186/s13045-018-0619-z29866190

 PubMed Web of Science ®Google Scholar

Zheng F, Chen J, Zhang X, et al. The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis. Nat Commun. 2021;12(1):1341. doi:10.1038/s41467-021-21535-333637716

 PubMed Web of Science ®Google Scholar

Yao Z, Zhang Q, Guo F, et al. Long noncoding RNA PCED1B-AS1 promotes the Warburg effect and tumorigenesis by upregulating HIF-1α in glioblastoma. Cell Transplant. 2020;29:963689720906777. doi:10.1177/096368972090677732326742

 PubMed Web of Science ®Google Scholar

Du Y, Wei N, Ma R, Jiang SH, Song D. Long noncoding RNA MIR210HG promotes the Warburg effect and tumor growth by enhancing HIF-1α translation in triple-negative breast cancer. Front Oncol. 2020;10:580176. doi:10.3389/fonc.2020.58017633392077

 PubMed Web of Science ®Google Scholar

Yang F, Zhang H, Mei Y, Wu M. Reciprocal regulation of HIF-1α and lincRNA-p21 modulates the Warburg effect. Mol Cell. 2014;53(1):88–100. doi:10.1016/j.molcel.2013.11.00424316222

 PubMed Web of Science ®Google Scholar

Lin A, Li C, Xing Z, et al. The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. Nat Cell Biol. 2016;18(2):213–224. doi:10.1038/ncb329526751287

 PubMed Web of Science ®Google Scholar

Hung CL, Wang LY, Yu YL, et al. A long noncoding RNA connects c-Myc to tumor metabolism. Proc Natl Acad Sci U S A. 2014;111(52):18697–18702. doi:10.1073/pnas.141566911225512540

 PubMed Web of Science ®Google Scholar

Tang J, Yan T, Bao Y, et al. LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc. Nat Commun. 2019;10(1):3499. doi:10.1038/s41467-019-11447-831375671

 PubMed Web of Science ®Google Scholar

Xiang S, Gu H, Jin L, Thorne RF, Zhang XD, Wu M. LncRNA IDH1-AS1 links the functions of c-Myc and HIF1α via IDH1 to regulate the Warburg effect. Proc Natl Acad Sci U S A. 2018;115(7):E1465–e74. doi:10.1073/pnas.171125711529378948

 PubMed Web of Science ®Google Scholar

Li W, Huang K, Wen F, et al. LINC00184 silencing inhibits glycolysis and restores mitochondrial oxidative phosphorylation in esophageal cancer through demethylation of PTEN. EBioMedicine. 2019;44:298–310. doi:10.1016/j.ebiom.2019.05.05531201145

 PubMed Web of Science ®Google Scholar

Zou ZW, Ma C, Medoro L, et al. LncRNA ANRIL is up-regulated in nasopharyngeal carcinoma and promotes the cancer progression via increasing proliferation, reprograming cell glucose metabolism and inducing side-population stem-like cancer cells. Oncotarget. 2016;7(38):61741–61754. doi:10.18632/oncotarget.1143727557514

 PubMedGoogle Scholar

Li Z, Li X, Wu S, Xue M, Chen W. Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway. Cancer Sci. 2014;105(8):951–955. doi:10.1111/cas.1246124890811

 PubMed Web of Science ®Google Scholar

Zheng YL, Li L, Jia YX, et al. LINC01554-mediated glucose metabolism reprogramming suppresses tumorigenicity in hepatocellular carcinoma via downregulating PKM2 expression and inhibiting Akt/mTOR signaling pathway. Theranostics. 2019;9(3):796–810. doi:10.7150/thno.2899230809309

 PubMed Web of Science ®Google Scholar

Cheng Z, Luo C, Guo Z. LncRNA-XIST/microRNA-126 sponge mediates cell proliferation and glucose metabolism through the IRS1/PI3K/Akt pathway in glioma. J Cell Biochem. 2020;121(3):2170–2183. doi:10.1002/jcb.2944031680298

 PubMed Web of Science ®Google Scholar

Chen Z, Li JL, Lin S, et al. cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth. J Clin Invest. 2016;126(6):2267–2279. doi:10.1172/jci8525027140397

 PubMed Web of Science ®Google Scholar

Kim SJ, Ju JS, Park SS, et al. An RNA-binding-protein, NONO governs energy metabolism by regulating NAMPT in lung cancer. Biochem Biophys Res Commun. 2020;528(2):376–382. doi:10.1016/j.bbrc.2020.01.01132087970

 PubMed Web of Science ®Google Scholar

Liu X, Xiao ZD, Han L, et al. LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nat Cell Biol. 2016;18(4):431–442. doi:10.1038/ncb332826999735

 PubMed Web of Science ®Google Scholar

Yang W, Zheng Z, Yi P, et al. LncRNA NBR2 inhibits the malignancy of thyroid cancer, associated with enhancing the AMPK signaling. Front Oncol. 2020;10:956. doi:10.3389/fonc.2020.0095632596161

 PubMed Web of Science ®Google Scholar

Chen R, Liu Y, Zhuang H, et al. Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation. Nucleic Acids Res. 2017;45(17):9947–9959. doi:10.1093/nar/gkx60028973437

 PubMed Web of Science ®Google Scholar

Uroda T, Anastasakou E, Rossi A, et al. Conserved pseudoknots in lncRNA MEG3 are essential for stimulation of the p53 pathway. Mol Cell. 2019;75(5):982–95.e9. doi:10.1016/j.molcel.2019.07.02531444106

 PubMed Web of Science ®Google Scholar

Zhang Y, Wu J, Jing H, Huang G, Sun Z, Xu S. Long noncoding RNA MEG3 inhibits breast cancer growth via upregulating endoplasmic reticulum stress and activating NF-κB and p53. J Cell Biochem. 2019;120(4):6789–6797. doi:10.1002/jcb.2798230556250

 PubMed Web of Science ®Google Scholar

Zhang H, Qin D, Jiang Z, Zhang J. SNHG9/miR-199a-5p/Wnt2 axis regulates cell growth and aerobic glycolysis in glioblastoma. J Neuropathol Exp Neurol. 2019;78(10):939–948. doi:10.1093/jnen/nlz07831504670

 PubMed Web of Science ®Google Scholar

Kang R, Yao DF, Xu GZ, Zhou YH. The knockdown of SNHG3 inhibits the progression of laryngeal squamous cell carcinoma by miR-340-5p/YAP1 axis and Wnt/β-catenin pathway. Neoplasma. 2020;67(5):1094–1105. doi:10.4149/neo_2020_191022N107332538668

 PubMed Web of Science ®Google Scholar

Lin X, Feng D, Li P, Lv Y. LncRNA LINC00857 regulates the progression and glycolysis in ovarian cancer by modulating the Hippo signaling pathway. Cancer Med. 2020;9(21):8122–8132. doi:10.1002/cam4.332232918541

 PubMed Web of Science ®Google Scholar

Zheng X, Han H, Liu GP, et al. LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism. EMBO J. 2017;36(22):3325–3335. doi:10.15252/embj.20179760928963395

 PubMed Web of Science ®Google Scholar

Mota MSV, Jackson WP, Bailey SK, et al. Deficiency of tumor suppressor Merlin facilitates metabolic adaptation by co-operative engagement of SMAD-Hippo signaling in breast cancer. Carcinogenesis. 2018;39(9):1165–1175. doi:10.1093/carcin/bgy07829893810

 PubMed Web of Science ®Google Scholar

Zhai H, Zhang X, Sun X, Zhang D, Ma S. Long non-coding RNA LINC01420 contributes to pancreatic cancer progression through targeting KRAS proto-oncogene. Dig Dis Sci. 2020;65(4):1042–1052. doi:10.1007/s10620-019-05829-731562613

 PubMed Web of Science ®Google Scholar

Zhai X, Xu W. Long noncoding RNA ATB promotes proliferation, migration, and invasion in bladder cancer by suppressing microRNA-126. Oncol Res. 2018;26(7):1063–1072. doi:10.3727/096504018x1515207209847629321082

 PubMed Web of Science ®Google Scholar

Yang W, Redpath RE, Zhang C, Ning N. Long non-coding RNA H19 promotes the migration and invasion of colon cancer cells via MAPK signaling pathway. Oncol Lett. 2018;16(3):3365–3372. doi:10.3892/ol.2018.905230127936

 PubMed Web of Science ®Google Scholar

Zhai S, Xu Z, Xie J, et al. Epigenetic silencing of LncRNA LINC00261 promotes c-myc-mediated aerobic glycolysis by regulating miR-222-3p/HIPK2/ERK axis and sequestering IGF2BP1. Oncogene. 2021;40(2):277–291. doi:10.1038/s41388-020-01525-3

 Google Scholar

Zhang G, Ma A, Jin Y, Pan G, Wang C. LncRNA SNHG16 induced by TFAP2A modulates glycolysis and proliferation of endometrial carcinoma through miR-490-3p/HK2 axis. Am J Transl Res. 2019;11(11):7137–7145.31814916

 PubMed Web of Science ®Google Scholar

Hua Q, Jin M, Mi B, et al. LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis. J Hematol Oncol. 2019;12(1):91. doi:10.1186/s13045-019-0773-y31488218

 PubMed Web of Science ®Google Scholar

Liu J, Liu ZX, Wu QN, et al. Long noncoding RNA AGPG regulates PFKFB3-mediated tumor glycolytic reprogramming. Nat Commun. 2020;11(1):1507. doi:10.1038/s41467-020-15112-332198345

 PubMed Web of Science ®Google Scholar

Liao M, Liao W, Xu N, et al. LncRNA EPB41L4A-AS1 regulates glycolysis and glutaminolysis by mediating nucleolar translocation of HDAC2. EBioMedicine. 2019;41:200–213. doi:10.1016/j.ebiom.2019.01.03530796006

 PubMed Web of Science ®Google Scholar

Hong J, Guo F, Lu SY, et al. F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer. Gut. 2020. doi:10.1136/gutjnl-2020-322780

 Web of Science ®Google Scholar

Hua Q, Mi B, Xu F, et al. Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis. Theranostics. 2020;10(11):4762–4778. doi:10.7150/thno.4383932308748

 PubMed Web of Science ®Google Scholar