Figures & data
Table 1 Peripheral Blood and Bone Marrow Trends Throughout Treatment Course
Figure 1 Karyotype. 46,XY,t(5;7;7) (q33.2; q32; q11.2). Arrows indicate the direction of the transfer of chromosomal material between the derivative chromosomes 5, 7 and 7.
![Figure 1 Karyotype. 46,XY,t(5;7;7) (q33.2; q32; q11.2). Arrows indicate the direction of the transfer of chromosomal material between the derivative chromosomes 5, 7 and 7.](/cms/asset/a2fb8321-6c78-48cb-9ad7-aa7020d63f8e/dcmr_a_12189870_f0001_c.jpg)
Figure 2 Metaphase FISH using break apart probes for 3ʹPDGFRB (red signal) and 5ʹPDGFRB (green signal). Arrow A shows the normal chromosome 5 with an intact PDGFRB fusion signal (yellow). Arrow B shows the derivative chromosome 5 containing only the 3ʹ portion of PDGFRB (red signal). Arrow C shows the derivative chromosome 7 with the translocated 5ʹ portion of PDGFRB (green signal).
![Figure 2 Metaphase FISH using break apart probes for 3ʹPDGFRB (red signal) and 5ʹPDGFRB (green signal). Arrow A shows the normal chromosome 5 with an intact PDGFRB fusion signal (yellow). Arrow B shows the derivative chromosome 5 containing only the 3ʹ portion of PDGFRB (red signal). Arrow C shows the derivative chromosome 7 with the translocated 5ʹ portion of PDGFRB (green signal).](/cms/asset/9d0fd168-1e97-44b0-aff1-6c832d64267a/dcmr_a_12189870_f0002_c.jpg)
Figure 3 Whole chromosome 5 paint with green fluorescent probes. Arrow A shows the normal chromosome 5 with fluorescence label seen throughout the chromosome indicating intact chromosomal material. Arrow B shows the derivative chromosome 5; the unlabeled end of the long arm indicates the translocated chromosomal material from the derivative chromosome 7. Arrow C shows the derivative chromosome 7 containing translocated material from the der(5).
![Figure 3 Whole chromosome 5 paint with green fluorescent probes. Arrow A shows the normal chromosome 5 with fluorescence label seen throughout the chromosome indicating intact chromosomal material. Arrow B shows the derivative chromosome 5; the unlabeled end of the long arm indicates the translocated chromosomal material from the derivative chromosome 7. Arrow C shows the derivative chromosome 7 containing translocated material from the der(5).](/cms/asset/7b31431c-9d99-459d-ab63-ef47c1c60c6e/dcmr_a_12189870_f0003_c.jpg)
Figure 4 Whole chromosome 7 paint with red fluorescent probes. Arrow A shows the derivative chromosome 7. Arrow B shows the derivative chromosome 7 with the unlabeled part at the end indicating the translocated chromosomal material from the derivative chromosome 5. Arrow C shows the der(5) with translocated chromosomal material from der(7).
![Figure 4 Whole chromosome 7 paint with red fluorescent probes. Arrow A shows the derivative chromosome 7. Arrow B shows the derivative chromosome 7 with the unlabeled part at the end indicating the translocated chromosomal material from the derivative chromosome 5. Arrow C shows the der(5) with translocated chromosomal material from der(7).](/cms/asset/570a1318-eec9-4efc-91d3-235fadd1a6a5/dcmr_a_12189870_f0004_c.jpg)