Changes in Carcinoid Syndrome Symptoms Among Patients Receiving Telotristat Ethyl in US Clinical Practice: Findings from the TELEPRO-II Real-World Study

Figures & data

Table 1 Baseline Demographic and Clinical Characteristics

Patients, n (%) Unless Noted Otherwise	All TE Patients (n=1318)	Analysis Cohort (n=684)	Discontinued TE (n=387)
Gender, female	713 (54)	367 (54)	223 (58)
Age, y
≤44	82 (6)	39 (6)	24 (6)
45–64	568 (43)	304 (44)	162 (42)
≥65	659 (50)	334 (49)	201 (52)
Not reported	9 (1)	7 (1)	0
Health insurance type
Commercial	568 (43)	285 (42)	180 (47)
Medicare	489 (37)	244 (36)	152 (39)
Medicaid	62 (5)	37 (5)	13 (4)
Other or unknown	199 (15)	118 (17)	42 (11)
Somatostatin analog treatment
Immediate release	91 (7)	62 (9)	26 (7)
Long-acting, octreotide	738 (56)	437 (64)	236 (61)
Long-acting, lanreotide	302 (23)	186 (27)	88 (23)
CS symptom burden, mean (SD)^a
Daily bowel movement frequency	5.1 (3.8), n=1318	6.3 (3.4), n=684	6.1 (3.2), n=387
Daily flushing episodes	3.0 (3.2), n=862	3.1 (3.3), n=538	3.0 (3.0), n=321
Stool consistency (1–10)	6.6 (2.0), n=1075	6.5 (1.8), n=681	6.7 (2.3), n=381
Nausea severity (0–10)	8.4 (2.9), n=223	8.4 (2.9), n=165	8.6 (3.1), n=56
Abdominal pain (0–10)	6.5 (3.2), n=726	6.8 (3.2), n=461	5.9 (3.1) n=264
Urgency severity (0–10)	8.2 (2.3), n=1034	8.3 (2.2), n=661	7.9 (2.3), n=369

Notes:^a0–10 scale: 0=R“no symptoms”, 10=“worst imaginable symptoms”; 1–10 scale: 1=“very hard”, 10=“watery”.

Abbreviations: CS, carcinoid syndrome; SD, standard deviation; TE, telotristat ethyl.

Figure 1 Patient eligibility for the TELEPRO-II analytic sample.

Figure 2 CS symptom mean changes from baseline. (A) Daily bowel movement frequency. (B) Stool consistency, nausea, abdominal pain, and urgency. (C) Daily flushing episodes. *P<0.0001.

Figure 3 Proportion of patients with improved CS symptoms (lower post-baseline symptom rating) by level of improvement in daily bowel movement frequency (≥30% decrease or <30% decrease).