Demographics, Changes in Treatment Patterns, and Outcomes of Bone and Soft Tissue Sarcomas in Korea—A Sarcoma-Specific, Institutional Registry-Based Analysis

Figures & data

Table 1 Baseline Characteristics

	Total n = 3420	Soft Tissue n = 2661	Bone n = 759
Baseline characteristics
Date of diagnosis
Pre-2000	391 (11.4%)	286 (10.7%)	105 (13.8%)
2000–2009	1222 (35.7%)	929 (34.9%)	293 (38.6%)
2010–2017	1807 (52.8%)	1446 (54.3%)	361 (47.6%)
Age at diagnosis
Median (range)	48 (16–98)	50 (16–98)	37 (16–85)
AYA (16–29)	2297 (67.2%)	303 (11.4%)	280 (36.9%)
Adult (30–64)	583 (17.0%)	1885 (70.8%)	412 (54.3%)
Elderly (≥65)	540 (15.8%)	473 (17.8%)	67 (8.8%)
Sex
Male	1612 (47.1%)	1212 (45.5%)	400 (52.7%)
Female	1808 (52.9%)	1449 (54.5%)	359 (47.3%)
Primary site
Head and neck	218 (6.4%)	157 (5.9%)	61 (8.0%)
Thorax	476 (13.9%)	393 (14.8%)	83 (10.9%)
Abdomen	800 (23.4%)	759 (28.5%)	41 (5.4%)
GU/GYN	503 (14.7%)	492 (18.5%)	11 (1.4%)
Extremities and skeleton	1279 (37.4%)	781 (29.3%)	498 (65.6%)
Others	108 (3.2%)	45 (1.7%)	63 (8.3%)
Unknown	36 (1.1%)	34 (1.3%)	2 (0.3%)
Initial treatment^†	Overall n = 3407^‡	Soft tissue n = 2651	Bone n = 756
Surgically treated patients	n = 3164	n = 2470	n = 694
Surgery only	2229 (65.4%)	1727 (65.1%)	502 (66.4%)
Neoadjuvant chemotherapy followed by surgery	131 (3.8%)	49 (1.8%)	82 (10.8%)
Surgery followed by adjuvant chemotherapy	483 (14.2%)	404 (15.2%)	79 (10.4%)
Surgery with perioperative radiotherapy without chemotherapy	321 (9.4%)	290 (10.9%)	31 (4.1%)
Non-surgically treated patients	n = 243	n = 181	n = 62
Chemotherapy only	149 (4.4%)	113 (4.3%)	36 (4.8%)
Radiotherapy only	42 (1.2%)	35 (1.3%)	7 (0.9%)
Chemotherapy and radiotherapy	52 (1.5%)	33 (1.2%)	19 (2.5%)

Notes: ^†Treatments were considered as given together if administered within a 6-month period. ^‡Analyzed 3407 patients whose treatment dates were available.

Abbreviations: AYA, adolescents and young adults; GU/GYN, genitourinary and gynecologic.

Figure 1 Pie chart for histologic diagnosis. (A) Soft tissue sarcoma. (B) Bone sarcoma.

Figure 2 Sankey diagram showing sequential treatment flow of the study population. (A) Soft tissue sarcoma. (B) Bone sarcoma.

Figure 3 Initial treatment pattern by year of diagnosis.

Note: Straight lines and dotted lines indicate soft tissue and bone sarcomas, respectively.

Abbreviations: CT, chemotherapy; OP, surgery; RT, radiotherapy.

Figure 4 Overall survival by (A) origin of tumors, (B) age at diagnosis, and (C) year of diagnosis.

Abbreviations: AYA, adolescents and young adults; GU/GYN, genitourinary and gynecologic.