Undifferentiated Pleomorphic Sarcoma with Neoplastic Fever: A Retrospective Study

Figures & data

Table 1 Clinical Characteristics of Patients with UPS with Neoplastic Fever

Patient No.	Sex	Age (Years)	ECOG PS	Primary Site	TNM Stage	Primary Size (cm)	Neoadjuvant Therapy	Recurrence	Metastasis	3-Year Survival
1	Female	68	0	Thigh	III	9.8	Unfinished	No	No	Yes
2	Male	54	1	Thigh	III	12.8	Unfinished	Yes	No	Yes
3	Male	65	0	Thigh	III	18.0	Unfinished	Yes	No	Yes
4	Male	57	1	Lower leg	III	9.6	Unfinished	No	No	Yes
5	Female	66	0	Upper arm	III	7.2	NA	Yes	No	Yes
6	Female	73	0	Upper arm	II	4.8	NA	No	No	Yes
7	Male	51	0	Thigh	III	15.0	Unfinished	Yes	Yes	No

Abbreviations: UPS, undifferentiated pleomorphic sarcoma; ECOG PS, Eastern Cooperative Oncology Group performance status; NA, not applicable.

Table 2 Comparison of Clinical Characteristics Between Patients with UPS with and without Neoplastic Fever

Characteristics	Fever UPS Group (n=7)	Normal UPS Group (n=89)
Gender
Male	4	49
Female	3	40
Age (years)	62±8.08	59±10.12
ECOG PS
0	5	76
1	2	13
Primary site
Upper arm	2	26
Thigh	4	54
Lower leg	1	9
Primary tumour size (cm)	11.02±4.56	7.28±6.83
Stage
II	1	18
III	6	71
Peritumor soft tissue edema and tumor necrosis (MR)
Yes	7	21
No	0	68
Postoperative adjuvant therapy
No	3	24
Yes	4	65
Recurrence rate	57.14% (4/7)	53.93% (48/89)
Metastasis rate	14.29% (1/7)	44.94% (40/89)
3-year survival rate	85.71% (6/7)	59.55% (53/89)

Note: Data are presented as numbers (percentages) or means ± standard deviations.

Abbreviations: UPS, undifferentiated pleomorphic sarcoma; ECOG PS, Eastern Cooperative Oncology Group performance status; MR, magnetic resonance imaging.

Figure 1 Pathological characteristics in all seven patients with UPS with fever (Fever UPS) and seven randomly selected patients with UPS without neoplastic fever (Normal UPS). Pathological manifestations were similar between the two groups. Histopathologically, all cases show high cellularity, myxoid area < 10%, and pleomorphic nuclear atypia.

Abbreviation: UPS, undifferentiated pleomorphic sarcoma.

Figure 2 MRI findings of all seven patients with UPS with fever (Fever UPS) and seven randomly selected patients with UPS without neoplastic fever (Normal UPS). In patients with UPS with neoplastic fever, MRI shows necrosis inside the tumor body; all tumors span the muscular space, and extensive soft tissue edema around the tumor is noted. Most cases of UPS without neoplastic fever did not exhibit these features on MRI.

Abbreviations: MRI, magnetic resonance imaging; UPS, undifferentiated pleomorphic sarcoma.