The effect of CyberKnife therapy on pulmonary function tests used for treating non-small cell lung cancer: a retrospective, observational cohort pilot study

Figures & data

Table 1 Patient characteristics

Age (median) (years)	73
Male-n (%)	19 (51)
Smoking-n (%)	37 (100)
Location
Left upper lobe-n (%)	13 (35)
Left lower lobe-n (%)	4 (11)
Right upper lobe-n (%)	7 (20)
Right medial lobe-n (%)	1 (3)
Right lower lobe-n (%)	10 (30)
Right hilar lymph nodal region-n (%)	2 (5)
Stage
Stage I-n (%)	22 (59)
Stage II-n (%)	2 (5)
Stage III-n (%)	5 (14)
Stage IV-n (%)	8 (22)
Dose of radiation received
5000 cGy-n (%)	3 (8)
6000 cGy-n (%)	34 (92)

Table 2 Comparison of pulmonary function tests pre- and post-CyberKnife treatment

Pulmonary function test results Pre-CyberKnife vs 3–4 months post-CyberKnife
PFT parameter (percentage of predicated)	Mean	n (number of patients)	Standard deviation	P-value
FVC – pre	76.2	37	21.6	0.346
FVC – post	74.2	37	19.6
FEV1 – pre	56.5	37	22.1	0.781
FEV1 – post	56.2	37	21.9
FEV1/FVC – pre	74.6	37	17.9	0.905
FEV1/FVC – post	74.8	37	18.0
FEF – pre	29.4	37	21.7	0.478
FEF – post	31.0	37	20.9
FIVC – pre	2.1	33	0.7	0.189
FIVC – post	2.2	33	0.8
SVC – pre	75.1	35	17.8	0.383
SVC – post	76.9	35	17.7
IC – pre	74.9	32	17.8	0.267
IC – post	72.1	32	20.9
ERV – pre	106.9	32	146.8	0.668
ERV – post	112.7	32	92.0
DLCO – pre	56.1	33	24.4	0.672
DLCO – post	54.8	33	19.8
DLVA – pre	79.6	32	30.5	0.287
DLVA – post	90.8	32	53.5
VA – pre	71.1	32	19.1	0.299
VA – post	67.0	32	21.4

Abbreviations: PFT, pulmonary function test; FVC, forced vital capacity; FEV₁, forced expiratory volume in 1 second; FEF, forced expiratory flow; FIVC, forced inspiratory vital capacity; SVC, slow vital capacity; IC, inspiratory capacity; ERV, expiratory reserve volume; DLCO, diffusing capacity of the lung for carbon monoxide; DLVA, diffusion capacity corrected for alveolar volume; VA, alveolar volume.

Figure 1 Comparison of mean pulmonary function tests before and 3–4 months after CyberKnife treatment in a stage 4 patient.

Abbreviations: Mos, months; FVC, forced vital capacity; FEV₁, forced expiratory volume in 1 second; FEF, forced expiratory flow; FIVC, forced inspiratory vital capacity.