All-Trans-Retinoic Acid Plus Oxaliplatin/Fluorouracil/Leucovorin for Advanced Hepatocellular Carcinoma with Pulmonary Metastasis: A Multicenter Retrospective Study

Figures & data

Table 1 The Clinicopathological Features of All Patients (n =66)

Variables	FOLFOX (n=32)	ATRA+FOLFOX (n=34)	P value
Age			0.339
≤50	17	22
>50	15	12
Sex			0.450
Male	25	29
Female	7	5
HBsAg			0.265
Negative	2	5
Positive	30	29
α-Fetoprotein			0.464
≤400	15	19
>400	17	15
ALT			0.923
≤44	22	23
>44	10	11
TB			0.321
>17.1	8	5
≤17.1	24	29
PLT			0.246
≥100	28	26
<100	4	8
WBC			0.510
≥4000	24	23
<4000	8	11
Hepatic tumor diameter			0.087
>5	16	10
≤5	16	24
Hepatic tumor number			0.336
>3	16	13
≤3	16	21
Lung metastasis number			0.397
>3	27	31
≤3	5	3
HBV-DNA			0.136
Positive	13	8
Negtive	19	26
CLIP score			0.085
<2	17	25
≥2	15	9
Okuda stage			0.670
I	23	26
II	9	8

Abbreviations: ATRA, all-trans-retinoic acid; FOLFOX4, infusional fluorouracil, leucovorin, and oxaliplatin; HBsAg, hepatitis B surface antigen; ALT, alanine aminotransferase; TB, total bilirubin; PLT, platelet; HBV-DNA, Hepatitis B virus DNA.

Figure 1 Kaplan–Meier curve of overall survival in the two groups.

Figure 2 Kaplan–Meier curve of disease-free survival in the two groups.

Table 2 Disease Response of the Two Groups of Patients

Parameter	ATRA+FOLFOX4(n=34)		FOLFOX4(n=32)		P
	No.	%	No.	%
RR^†	10	29.4%	3	9.4%	0.041
DCR^‡	20	58.8%	8	25.0%	0.005
CR	3	8.8%	0	0	0.085
PD	14	41.2%	24	75.0%	0.005

Notes: ^†Defined as complete response (CR), plus partial response (PR). ^‡Defined as omplete response (CR), plus partial response (PR), plus stable disease (SD).

Abbreviations: ATRA, all-trans-retinoic acid; CR, complete response; DCR, disease control rate; FOLFOX4, infusional fluorouracil, leucovorin, and oxaliplatin; PD, progressive disease; RR, response rate.

Table 3 Adverse Events of Patients with Advanced HCC Who Underwent Chemotherapy

Adverse Event	No. of Patients with CTCAE Grade3/4(n)
	FOLFOX4	ATRA+FOLFOX
Headache	–	–
Fatigue	–	–
Nausea	2	2
Vomit	2	1
Diarrhea	–	–
Thrombocytopenia	–	–
Leukocytopenia	9	9
ALT increase	1	–
Bilirubin increase	–	–
Hypoalbuminemia	–	–

Abbreviations: ATRA, all-trans-retinoic acid; FOLFOX4, infusional fluorouracil, leucovorin, and oxaliplatin.