Nomogram to Predict Radiation Enteritis in Cervical Squamous Cell Carcinoma

Figures & data

Table 1 The Characteristics of Patients with RE

Characteristics	RE (n=32)	nRE (n=58)
Age (years)
≥60	11(0.34)	24(0.41)
<60	21(0.66)	34(0.59)
History of hypertension
Yes	6(0.19)	12(0.21)
No	26(0.81)	46(0.79)
History of diabetes
Yes	3(0.09)	7(0.12)
No	29(0.91)	51(0.88)
FIGO stage
I–III	29(0.91)	50(0.86)
IV	3(0.09)	8(0.14)
Induction chemotherapy
Yes	8(0.25)	15(0.26)
No	24(0.75)	43(0.74)
Concurrent chemotherapy
Yes	20(0.63)	30 (0.52)
No	12(0.37)	28(0.48)
History of abdominal/pelvic surgery
Yes	4(0.12)	8(0.14)
No	28(0.88)	50(0.86)
Internal irradiation
Yes	28(0.88)	41 (0.71)
No	4(0.12)	17(0.29)
Paraaortic radiation
Yes	2(0.06)	3(0.05)
No	30(0.94)	55(0.95)
Definitive radiation
Yes	31(0.97)	57(0.99)
No	1(0.03)	1(0.01)
Primary radiation
Yes	32(1)	58(1)
No	0(0)	0(0)
Two treatment plans
Yes	9(0.28)	16(0.28)
No	23(0.72)	42(0.72)

Table 2 ROC Curve Analysis of Continuous Clinical Data in the Diagnosis of RE

Variable	AUC	Best Cutoff	Sensitivity	Specificity	p-value
Age (years)	0.53	51	75.76	42.11	0.60
CD4/CD8	0.53	1.19	39.94	78.90	0.62
Uxiliary/induced T cells	0.51	50.05	6.1	82.5	0.94
Inhibitory/cytotoxic T cells	0.53	29.53	33.3	78.9	0.70
HGB (g/L)	0.51	97	33.33	89.5	0.94
ALB (g/L)	0.53	40.6	45.45	73.68	0.65
External radiation dose (Gy)	0.54	50	66.67	52.63	0.47
Total B lymphocyte count (%)	0.53	11.85	78.8	35.1	0.62
Total T lymphocyte count (%)	0.58	66.78	72.7	47.4	0.21
Small intestine V45	0.53	6.35	48.4	63.2	0.63
Sigmoid colon V45	0.58	69.77	74.2	45.6	0.23
Rectum V45	0.51	40.9	87.1	24.6	0.93
Sigmoid colon D2cc	0.53	72.09	87.5	26.3	0.61
Rectum D2cc	0.51	79.88	93.9	15.8	0.94

Table 3 Univariate Analysis of the Factors Associated with RE

Characteristics	HR	95% CI	p-value
CD4/CD8	1.88	0.71~6.96	0.201
HGB	4.25	1.43~13.73	0.011
ALB	2.33	0.95~5.83	0.066
Uxiliary/induced T cells	0.40	0.06~1.70	0.259
History of hypertension	3.57	1.24~10.90	0.020
Age	2.27	0.90~6.18	0.092
History of abdominal/pelvic surgery	0.84	0.21~2.94	0.797
History of diabetes	1.17	0.28~ 4.44	0.817
Concurrent chemotherapy	0.64	0.27~ 1.51	0.306
Induction chemotherapy	0.84	0.31~2.09	0.708
External radiation dose	0.45	0.18~1.08	0.079
Inhibitory/cytotoxic T cells	1.88	0.71~4.96	0.201
Iinternal brachytherapy	1.61	0.58~4.97	0.381
Total B lymphocyte count	1.56	0.61~4.29	0.366
Total T lymphocyte count	2.4	0.97~6.29	0.064
Small intestine V45	0.60	0.23~1.49	0.278
Sigmoid colon V45	0.41	0.15~1.03	0.066
Rectum V45	1.23	0.52~2.94	0.637
Sigmoid colon D2cc	0.47	0.12~1.47	0.219
Rectum D2cc	0.34	0.05~1.45	0.190

Table 4 Multivariate Analysis of the Factors Associated with RE

Characteristics	HR	95% CI	p-value
Sigmoid colon V45	0.41	0.11~1.31	0.146
HGB	13.23	3.03~72.65	0.001
ALB	6.76	2.08~25.57	0.003
History of hypertension	4.20	0.95~21.14	0.066
Age	2.76	0.81~10.68	0.120
External radiation dose	0.47	0.14~1.44	0.194
Total T lymphocyte count	4.79	1.45~18.38	0.015

Figure 1 Nomogram for the individualized prediction of RE in cervical cancer patients.

Figure 2 (A) ROC curve for the prediction nomogram. (B) Calibration curve showing nomogram-predicted RE probabilities compared with the actual RE.