Improvements in Survival and Early Retirement Rates – Real-World Evidence on Danish Breast Cancer Patients 2004–2018

Figures & data

Table 1 Criteria for Pathology Subgroup

Subgroup	SNOMED Combination		SNOMED Combination
HER2-Positive	T04 and F29603	OR	T04 and FE13B5
HER2-Negative	T04 and F29601	OR	T04 and FE13B1
ER-Positive	T04 and F29521
ER-Negative	T04 and F29525
Triple-negative	T04 and F29601 and F29525	OR	T04 and FE13B1 and F29525

Figure 1 Flowchart from identification of cases to matching of main datasets.

Table 2 Summary Statistics, Breast Cancer Patients and Their Spouses

Characteristics	BC, N = 69,403	Spouse, N = 50,581
Age	64 (54, 73)	63 (54, 72)
Sex
Male	0 (0%)	50,443 (100%)
Female	69,403 (100%)	138 (0.3%)
Treatment status
After	61,557 (89%)	43,461 (86%)
Before	7846 (11%)	7120 (14%)
Income	0 (0, 293,677)	36,057 (0, 406,043)
Education
Primary or no education	26,001 (37%)	15,228 (30%)
Short higher education	38,154 (55%)	30,868 (61%)
Long higher education	2918 (4.2%)	3078 (6.1%)
Un-known education	2330 (3.4%)	1407 (2.8%)
Region
Capital	21,687 (31%)	14,366 (28%)
Central Jutland	14,515 (21%)	10,975 (22%)
Northern Jutland	6915 (10.0%)	5271 (10%)
Zealand	11,029 (16%)	8358 (17%)
Southern Denmark	15,257 (22%)	11,611 (23%)

Note: Median or nominal values with inter quartile range or ratio in parenthesis.

Table 3 Summary Statistics, Matched Breast Cancer Sample Before/After

Characteristic	Overall, N = 29,463	After, N = 21,909	Before, N = 7554
Age	62 (53, 72)	62 (53, 72)	62 (53, 72)
Income one year before diagnosis	0 (0, 298,570)	0 (0, 303,094)	0 (0, 286,793)
Education
Primary or no education	12,445 (42%)	9387 (43%)	3058 (40%)
Short higher education	15,286 (52%)	11,534 (53%)	3752 (50%)
Long higher education	667 (2.3%)	426 (1.9%)	241 (3.2%)
Unknown education	1065 (3.6%)	562 (2.6%)	503 (6.7%)
Stage
Stage 1	8342 (28%)	6252 (29%)	2090 (28%)
Stage 2	13,498 (46%)	10,104 (46%)	3394 (45%)
Stage 3a	2345 (8.0%)	1703 (7.8%)	642 (8.5%)
Stage 3b	1527 (5.2%)	1091 (5.0%)	436 (5.8%)
Stage 4	1680 (5.7%)	1213 (5.5%)	467 (6.2%)
Unknown	2071 (7.0%)	1546 (7.1%)	525 (6.9%)
Region
Capital	9607 (33%)	7137 (33%)	2470 (33%)
Central Jutland	5745 (19%)	4279 (20%)	1466 (19%)
Northern Jutland	2750 (9.3%)	2034 (9.3%)	716 (9.5%)
Zealand	4870 (17%)	3620 (17%)	1250 (17%)
Southern Denmark	6491 (22%)	4839 (22%)	1652 (22%)

Note: Median or nominal values with inter quartile range or ratio in parenthesis.

Table 4 Hazard Ratios for Overall Mortality

Analysis	n Before/After	No. Events Before/After	Hazard Ratio	Confidence Interval	p-value
Before/After (All)	7554/21,909	3784/6935	0.86	0.82–0.90	<0.001
Stage 1–3	6596/13,139	2933/3693	0.84	0.80–0.88	<0.001
Stage 4	477/946	430/683	0.99	0.88–1.13	0.96
HER2-positive	1150/3266	612/856	0.72	0.65–0.81	<0.001
ER-positive/HER2-negative	6414/19,118	3165/6304	0.88	0.84–0.92	<0.001
Triple-negative	5290/5285 /5290 (TN)	2642/2005 /1976 (TN)	Before: 0.71 After: 0.62	Before: 0.67–0.76 After: 0.58–0.66	Before: <0.001 After < 0.001
Unmatched Before/After	7846/61,557	4020/15,356	0.82	0.79–0.85	<0.001
Unmatched 2004–2007	7846/8222	4020/3722	0.92	0.88–0.96	<0.001

Note: Before sample as reference for HR.

Table 5 Hazard Ratios for Early Retirement

Analysis	n Before/After	No. Events Before/After	Hazard Ratio	Confidence Interval	p-value
Before/After	3845/7233	504/447	0.85	0.74–0.97	0.016
Stage 1–3	3597/5069	429/307	0.9	0.77–1.05	0.196
Stage 4	176/230	52/52	0.9	0.61–1.33	0.598
HER2-positive	736/1214	138/141	0.92	0.72–1.18	0.52
ER-positive/HER2-negative	3327/7338	424/481	0.91	0.79–1.04	0.17
Triple-negative	2561/2157 /1609 (TN)	315/159/133 (TN)	Before: 0.92 After: 0.85	Before: 0.74–1.13 After: 0.67–1.07	Before: 0.409 After: 0.160
Spouses	4161/6292	132/83	0.86	0.63–1.16	0.324
Unmatched Before/After	3931/16,079	516/914	0.84	0.74–0.94	0.003
Unmatched 2004–2007	3931/3993	516/410	0.89	0.78–1.02	0.098

Notes: Before sample as reference for HR. End date: 1 January 2013 due to reform in the criteria for early retirement. n indicates at-risk patients in each group.