75
Views
2
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Development and Validation of a Comprehensive Model for Predicting Distant Metastasis of Solid Lung Adenocarcinoma: 3D Radiomics, 2D Radiomics and Clinical Features

, , , , , , , , , & ORCID Icon show all
Pages 3437-3448 | Received 18 Oct 2022, Accepted 19 Nov 2022, Published online: 27 Nov 2023

Figures & data

Figure 1 Patient recruitment process.

Abbreviation: DM, distant metastases.
Figure 1 Patient recruitment process.

Figure 2 Flowchart of this study: 3D and 2D ROI segmentation (A), feature extraction (B), feature selection and model development (C), and model evaluation (D).

Figure 2 Flowchart of this study: 3D and 2D ROI segmentation (A), feature extraction (B), feature selection and model development (C), and model evaluation (D).

Table 1 Univariate Analysis of the Training Set and the Test Set

Table 2 Multivariate Logistic Regression Analysis of the Training Set

Table 3 Performance Evaluation of Five Models in the Training Set and the Test Set

Figure 3 Receiver operating characteristic curves of five models in training set (A) and test set (B).

Figure 3 Receiver operating characteristic curves of five models in training set (A) and test set (B).

Figure 4 Decision curve analysis for five models in training set (A) and test set (B). The y-axis represents the net benefit and the x-axis represents the threshold probability. The black, red, green, blue, and purple lines represent the net gains for model 1, model 2, model 3, model 4, and model 5, respectively. The gray line represents the assumption that all patients had distant metastases. The black line represents the assumption that all patients had no distant metastases.

Figure 4 Decision curve analysis for five models in training set (A) and test set (B). The y-axis represents the net benefit and the x-axis represents the threshold probability. The black, red, green, blue, and purple lines represent the net gains for model 1, model 2, model 3, model 4, and model 5, respectively. The gray line represents the assumption that all patients had distant metastases. The black line represents the assumption that all patients had no distant metastases.

Figure 5 Nomogram for model 5.

Abbreviation: c-radscore, radiomic score combining 3D and 2D radiomic features.
Figure 5 Nomogram for model 5.

Figure 6 Calibration curves of model 5 in training set (A) and test set (B).

Figure 6 Calibration curves of model 5 in training set (A) and test set (B).