The Potential Prognostic Marker TyG Index Predicts Time to Brain Metastasis at HER2 Positive Breast Cancer

Figures & data

Table 1 Baseline Characteristics of Patients

	All Patients
	n=120	(%)
Age - years, median (IQR)	48 (42–55)
Gender
Male	0	(0)
Female	120	(100)
Smoke
Yes	13	(10.8)
No	107	(89.2)
Her2 Status
+2 (SISH positive)	6	(5)
+3	114	(95)
Hormone Receptor Positivity
Yes	72	(60)
No	45	(37.5)
Unknown	3	(2.5)
Other Metastatic Areas
Lymph Nodes	96	(80)
Bone	66	(55)
Lung	51	(42.5)
Metastasectomy for Brain
Yes	15	(12.5)
No	105	(87.5)
Radiotherapy for Brain
Yes	109	(90.8)
No	11	(9.2)

Abbreviations: Her2, Human Epidermal Growth Factor Receptor 2; SISH, Silver In Situ Hybridization.

Table 2 Correlation Analyzes for Time to Brain Metastasis

	r	p value
TyG	−0.488	<0.001
TG/HDL-C	−0.269	0.003
Triglyceride	−0.78	0.39
Glucose	−0.086	0.35
HDL-C	+0.098	0.28

Abbreviations: TyG, Triglyceride Glucose Index; TG/HDL-C, Triglyceride to High-Density Lipoprotein; HDL-C cholesterol, High-Density Lipoprotein cholesterol.

Figure 1 Time to Brain Metastasis by TyG index.

Abbreviation: TyG, triglyceride-glucose index.

Table 3 Survival Outcomes

	Time To Brain Metastasis			OS
	Month	95% CI	p value	Month	95% CI
All patients	22	17.22–26.73		47	40.54–53.45
TyG Low	35	20.90–49.09	<0.001
High	15	8.92–21.07
TG/HDL-C Low	27	20.49–33.50	0.084
High	20	16.76–23.23

Abbreviations: OS, Overall Survival; TyG, Triglyceride Glucose Index; TG/HDL-C, Triglyceride to High-Density Lipoprotein cholesterol.

Data Sharing Statement

All data are available from the corresponding author upon reasonable request.