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Cancer Management and Research Volume 15, 2023 - Issue
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CASE REPORT

A Metastatic Pulmonary Sarcomatoid Carcinoma Patient Harboring KIF5B-RET Fusion Responds to First-Line Pralsetinib Treatment: A Case Report

Hao Qin1 Department of Respiratory and Critical Care Medicine, Shanghai Changhai Hospital, The First Affiliated Hospital of Second Military Medical University, Shanghai, People’s Republic of ChinaView further author information
,
Yuxiang Wan2 Department of Laboratory Diagnosis, Shanghai Changhai Hospital, The First Affiliated Hospital of Second Military Medical University, Shanghai, People’s Republic of ChinaView further author information
,
Yuchao Dong1 Department of Respiratory and Critical Care Medicine, Shanghai Changhai Hospital, The First Affiliated Hospital of Second Military Medical University, Shanghai, People’s Republic of ChinaCorrespondence[email protected] [email protected]
View further author information
&
Qinying Sun1 Department of Respiratory and Critical Care Medicine, Shanghai Changhai Hospital, The First Affiliated Hospital of Second Military Medical University, Shanghai, People’s Republic of ChinaView further author information
Pages 765-769 | Received 30 Mar 2023, Accepted 10 Jul 2023, Published online: 26 Jul 2023

Figures & data

Figure 1 Summary of disease course, therapies, and molecular findings. (A) The entire treatment course; (B) Chest CT scans of the primary PSC at treatment milestones; red arrows indicate nodular thickening of the pleura. (C) Pleuroscopy revealed multiple neoplasms in the right parietal pleura, visceral pleura, and phrenic pleura.

Abbreviations: CT, computed tomography; NGS, next-generation sequencing; PR, partial response; PSC, pulmonary sarcomatoid carcinoma.
Figure 1 Summary of disease course, therapies, and molecular findings. (A) The entire treatment course; (B) Chest CT scans of the primary PSC at treatment milestones; red arrows indicate nodular thickening of the pleura. (C) Pleuroscopy revealed multiple neoplasms in the right parietal pleura, visceral pleura, and phrenic pleura.

Figure 2 Hematoxylin-eosin (HE) and immunohistochemistry staining on the biopsy sample of the right parietal pleura. The rulers in indicate 50 μm.

Figure 2 Hematoxylin-eosin (HE) and immunohistochemistry staining on the biopsy sample of the right parietal pleura. The rulers in Figure 2 indicate 50 μm.

Figure 3 The integrative genomics viewer (IGV) screenshots revealed the harboring of KIF5B-RET fusion.

Figure 3 The integrative genomics viewer (IGV) screenshots revealed the harboring of KIF5B-RET fusion.

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