Preoperative Prognostic Nutritional Index Predict Survival in Patients with Resectable Adenocarcinoma of the Gastroesophageal Junction: A Retrospective Study Based on Propensity Score Matching Analyses

Figures & data

Figure 1 Receiver operating characteristic curve was plotted to determine the best cut-off value for the PNI.

Table 1 Relationships Between PNI and Clinicopathological Before and After Propensity Score Matched

Characteristic	All Patients (n=236)				Propensity Matching Patients (n=143)
	Total Patients	PNI <45.6 (n=67)	PNI ≥45.6 (n=169)	P	Total Patients	PNI <45.6 (n=58)	PNI ≥45.6 (n=85)	P
Male	171	46	125	0.411	101	42	59	0.699
Female	65	21	44		42	16	26
Age (years)		41.94±2.76	44.37±5.02	<0.001		42.16±2.64	42.96±4.17	0.158
BMI		20.19±2.21	21.30±2.24	0.001		20.41±2.22	20.52±2.22	0.762
Tumor diameter(cm)		5.445±1.90	4.53+1.90	0.001		5.32±1.92	5.24±1.97	0.814
ECOG scale								0.651
0	161	46	115	0.928	104	41	63
1	75	21	54		39	17	22
Differentiation				0.105				0.183
Well	36	11	25		21	10	11
Moderate	106	23	83		60	19	41
Poor	94	33	61		62	29	33
Pathological T stage				0.022				0.788
T1	17	1	16		5	1	4
pT1	9	1	8		2	1	1
ypT1	8	0	8		3	0	3
T2	13	2	11		3	1	2
T3	49	10	39		23	9	14
T4	157	54	103		112	47	65
Pathological N stage				<0.001				0.935
N0	77	9	68		20	8	12
N1	47	15	32		35	15	20
N2	58	19	39		41	15	26
N3	54	24	30		47	20	27
Pathological stage				0.006				0.742
I	48	7	41		21	7	14
II	53	11	42		25	11	14
III	135	49	86		97	40	57

Abbreviation: ECOG, Eastern Cooperative Oncology Group.

Figure 2 Kaplan-Meier curves of RFS based on PNI group in 143 patients with AGE.

Figure 3 Kaplan-Meier curves of OS based on PNI group in 143 patients with AGE.

Table 2 Prognostic Factors for Overall Survival in Patients with AGE After Propensity Score Matching

Variables	Patients (n = 143)	Category	Univariate			Multivariate
			HR	95% CI	p value	HR	95% CI	p value
Gender	101/42	Male/Female	1.236	0.654–2.339	0.514
Age	101/42	<45/≥45	1.153	0.610–2.181	0.661
BMI	40/103	<20/≥20	0.849	0.461–1.564	0.600
Pathological T stage	31/112	T1,T2,T3/T4	0.813	0.394–1.679	0.576
Pathological stage	46/97	I, II/ III	1.126	0.623–2.035	0.694
Tumor diameter	55/88	<5cm/≥5cm	1.384	0.781–2.452	0.265
Pathological N stage	55/88	N0,N1/N2,N3	0.415	0.212–0.815	0.011	0.399	0.203–0.784	0.008
PNI	58/85	<45.6/≥45.6	2.334	1.307–4.203	0.004	2.442	1.356–4.395	0.003

Abbreviations: HR, hazard ratio; CI, confidence interval.