Role of tolvaptan in the management of hyponatremia in patients with lung and other cancers: current data and future perspectives

Figures & data

Table 1 Subtypes of vasopressin receptors, location, and function

Receptor	Location	Function
V1A	Vascular smooth muscle, platelet, hepatocyte, myometrium	Vasoconstriction, platelet aggregation, myocardial hypertrophy
V1B	Anterior pituitary	Release of ACTH, prolactin, and endorphins
V2	Collecting duct of kidney, vascular endothelium, and vascular smooth muscle cell	Insertion of AQP2 channels into apical membrane of collecting duct, release of von Willebrand factor, and factor VIII

Abbreviation: ACTH, adrenocorticotropic hormone.

Figure 1 Mechanism of action of ADH and site of action of tolvaptan.

Abbreviations: ACS, adenyl cyclase system; ADH, antidiuretic hormone; PKA, protein kinase A; V2R, V2 receptor.