Targeted treatment of recurrent platinum-resistant ovarian cancer: current and emerging therapies

Figures & data

Table 1 Current clinical trials involving targeted agents in platinum-resistant epithelial ovarian cancer

Process	Molecular target	Agent	Trial phase	Additional agents	ClinicalTrials.gov identifier
Anti-tumor immunity	MUC1	MUC1-KLH vaccine	I	Adjuvant QS21	NCT00006041
Anti-tumor immunity	Whole tumor cell	Dendritic cells	II	Ontak	NCT00703105
			1	Bevacizumab/cyclophosphamide	NCT00683241
			0	Daclizumab/bevacizumab	NCT01132014
Anti-tumor immunity	Whole tumor cell	Adoptive transfer of T lymphocytes	I/II	tumor lysate-pulsed dendritic cells	NCT00603460
Angiogenesis	VEGF	Bevacizumab	III	Paclitaxel/topotecan/PLD	NCT00976911
			II	Gemcitabine	NCT01131039
			II	PLD	NCT00846612
			II	PLD	NCT00945139
			II	Abraxane	NCT00407563
Angiogenesis	VEGFR-2	Ramucirumab	II	N/A	NCT00721162
Angiogenesis	VEGF	Aflibercept (VEGF Trap)	I/II	Docetaxel	NCT00436501
Angiogenesis	VEGFR2	Cediranib	III	Carboplatin/paclitaxel	NCT00544973
Angiogenesis	VEGFR2	Vandetanib	I/II	PLD	NCT00862836
Cellular proliferation	EGFR		II	Docetaxel	NCT 00872989
Angiogenesis Cellular proliferation	EGFR	Panitumumab	II	PLD	NCT00861120
Angiogenesis	EGFR	Erlotinib	II	Topotecan	NCT01003938
Cellular proliferation			II	Bevacizumab	NCT00126542
			II	Bevacizumab	NCT00696670
Angiogenesis	VEGFR	Sorafenib	II	Topotecan	NCT01047891
	PDGFR C-Kit		II	Gemcitabine	NCT00096395
Angiogenesis	PDGFRα	IMC3G3	II	PLD	NCT00913835
Folate metabolism	FRα	MORAb-003	II	Paclitaxel	NCT00738699
DNA repair	PARP	Veliparib	I	PLD	NCT01145430
DNA repair	PARP	Iniparib	II	Gemcitabine	NCT01033292

Abbreviations: MUC1, mucin 1; VEGF, vascular endothelial growth factor; PLD, pegylated liposomal doxorubicin; VEGFR-2, vascular endothelial growth factor receptor 2; N/A, not applicable; EGFR, epidermal growth factor receptor; PDGFRα, platelet derived endothelial growth factor receptor alpha; FRα, folate receptor alpha; PARP, poly-ADP-ribose polymerase.