The association between risk of airflow limitation and serum uric acid measured at medical health check-ups

Figures & data

Table 1 Comparison of individual parameters between subjects with and without AL

	Total (n=8,662)	AL (+) (n=156)	AL (−) (n=8,506)	P-value
Gender (male/female)	5,191/3,471	117/39	5,074/3,432	<0.001
Age, years	52.5 (7.6)	58.4 (8.1)	52.4 (7.6)	<0.001
Smoking index	260 (361)	555 (501)	254 (356)	<0.001
Smoking status (C/F/N)	2,493/1,896/4,273	65/49/42	2,428/1,847/4,231	<0.001
Respiratory symptoms (±)	1,179/7,483	45/111	1,134/7,372	<0.001
Height, cm	163.0 (8.8)	163.7 (7.9)	162.9 (8.8)	0.2
Body weight, kg	62.8 (11.2)	60.9 (11.8)	62.8 (11.1)	0.02
BMI, kg/m^2	23.6 (3.1)	22.6 (3.4)	23.6 (3.1)	<0.001
%VC, %	101.6 (14.2)	92.0 (20.8)	101.7 (14.0)	<0.001
FEV1/FVC, %	84.0 (6.2)	63.9 (6.1)	84.3 (5.5)	<0.001
Mean BP, mmHg	91.9 (11.7)	91.9 (12.0)	91.9 (11.7)	0.9
WBC,/μL	5,635 (1,631)	6,090 (1,922)	5,627 (1,624)	0.003
TP, g/dL	7.2 (0.4)	7.1 (0.4)	7.2 (0.4)	0.01
Crea, mg/dL	0.8 (0.3)	0.8 (0.2)	0.8 (0.3)	0.8
HbA1c, %	5.3 (0.8)	5.4 (0.8)	5.2 (0.8)	0.05
TC, mg/dL	202.7 (33.1)	198.0 (33.2)	202.8 (33.0)	0.06
HDL-C, mg/dL	56.6 (14.0)	55.6 (13.6)	56.6 (14.0)	0.3

Note: Data are presented as mean (SD) unless otherwise indicated.

Abbreviations: AL, airflow limitation; C, current smoker; F, former smoker; N, never-smoker; BMI, body mass index; VC, vital capacity; FEV₁, forced expiratory volume in 1 second; FVC, forced vital capacity; BP, blood pressure; WBC, white blood cell; TP, total protein; Crea, creatinine; HbA1c, hemoglobin A1c; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; SD, standard deviation.

Figure 1 s-UA levels in subjects with and without airflow limitation.

Notes: Former and current smokers without AL had higher s-UA levels compared to never-smokers without AL. Additionally, subjects with AL also had higher s-UA levels than never-smokers without AL.
Abbreviations: s-UA, serum uric acid; AL, airflow limitation.

Table 2 Correlation analysis between FEV₁ %predicted and parameters measured at medical health check-ups

	r	P-value
Age	0.13	<0.001
Smoking index	−0.14	<0.001
BMI	−0.05	<0.001
Mean BP	−0.03	0.002
WBC	−0.12	<0.001
TP	−0.01	0.3
Crea	0.003	0.7
HbA1c	−0.06	<0.001
s-UA	−0.06	<0.001
TC	0.006	0.5
HDL-C	0.11	<0.001

Note: Data are presented as r value.

Abbreviations: FEV₁, forced expiratory volume in 1 second; BMI, body mass index; BP, blood pressure; WBC, white blood cell; TP, total protein; Crea, creatinine; HbA1c, hemoglobin A1c; s-UA, serum uric acid; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol.

Figure 2 Relationship between FEV₁ %predicted and s-UA.

Note: A weak but significant correlation was observed between FEV₁ %predicted and s-UA.
Abbreviations: FEV₁, forced expiratory volume in 1 second; s-UA, serum uric acid.

Table 3 Multiple logistic regression analysis (association with AL)

	OR	95% CI	P-value
Gender	0.885	0.506–1.549	0.6
Age	1.093	1.071–1.116	<0.001
Smoking index	1.001	1.001–1.001	<0.001
Smoking status	0.940	0.705–1.255	0.6
Respiratory symptoms	2.017	1.392–2.921	<0.001
BMI	0.855	0.804–0.909	<0.001
WBC	1.088	0.988–1.197	0.08
TP	0.836	0.538–1.299	0.4
Crea	0.323	0.097–1.080	0.06
HbA1c	1.036	0.859–1.251	0.7
s-UA	1.158	1.003–1.337	0.04
TC	0.998	0.993–1.003	0.4

Note: Data are presented as adjusted OR and 95% CI.

Abbreviations: AL, airflow limitation; OR, odds ratio; CI, confidence interval; BMI, body mass index; WBC, white blood cell; TP, total protein; Crea, creatinine; HbA1c, hemoglobin A1c; s-UA, serum uric acid; TC, total cholesterol.