Figures & data
Figure 1 PICO chart detailing inclusion in systematic review.
Abbreviations: AATD, alpha-1 antitrypsin deficiency; AAT, alpha-1 antitrypsin; Pi, protease inhibitor; COPD, chronic obstructive pulmonary disease; PICO, population, interventions, comparators, and outcomes.
![Figure 1 PICO chart detailing inclusion in systematic review.](/cms/asset/aba985d7-6117-4ae9-aeba-5c34d3f2d6f6/dcop_a_130440_f0001_c.jpg)
Figure 2 PRISMA flow diagram.
Abbreviation: COPD, chronic obstructive pulmonary disease.
![Figure 2 PRISMA flow diagram.](/cms/asset/ccf5bcec-22bf-48ef-867a-1732f7a742fb/dcop_a_130440_f0002_c.jpg)
Figure 3 Forest plots of the objective results from meta-analysis of augmentation trials.
Notes: (A) Mean annual change in lung density. (B) Mean FEV1 % predicted. (C) Standardized mean difference in DLCO. Differences in units used for DLCO (mmol/min/kPa and mL/mmHg/min) and the use of percentage change from baseline in RAPID, but annual change in the other studies required the use of a standardized mean difference plot.
Abbreviations: FEV1, forced expiratory volume in one second (L); DLCO, diffusing capacity of the lungs for carbon monoxide; mmol/min/kPa, millimole per minute per kilopascal; mL/mmHg/min, milliliter per millimeter of mercury per minute; SD, standard deviation; CI, confidence interval; df, degrees of freedom; Std, standard; IV, inverse variance.
![Figure 3 Forest plots of the objective results from meta-analysis of augmentation trials.Notes: (A) Mean annual change in lung density. (B) Mean FEV1 % predicted. (C) Standardized mean difference in DLCO. Differences in units used for DLCO (mmol/min/kPa and mL/mmHg/min) and the use of percentage change from baseline in RAPID, but annual change in the other studies required the use of a standardized mean difference plot.Abbreviations: FEV1, forced expiratory volume in one second (L); DLCO, diffusing capacity of the lungs for carbon monoxide; mmol/min/kPa, millimole per minute per kilopascal; mL/mmHg/min, milliliter per millimeter of mercury per minute; SD, standard deviation; CI, confidence interval; df, degrees of freedom; Std, standard; IV, inverse variance.](/cms/asset/adb58aee-b219-4f09-8458-13141deb09a4/dcop_a_130440_f0003_c.jpg)
Figure 4 Forest plots for patient-reported outcomes.
Abbreviations: SGRQ, St Georges Respiratory Questionnaire; SD, standard deviation; CI, confidence interval; df, degrees of freedom; IV, inverse variance.
![Figure 4 Forest plots for patient-reported outcomes.](/cms/asset/2da89e21-8da7-4f15-be08-ad7cbad3ba3b/dcop_a_130440_f0004_c.jpg)
Figure 5 Risk of bias in included studies.
Abbreviation: RCT, randomized controlled trial.
![Figure 5 Risk of bias in included studies.](/cms/asset/eda7dd20-0037-4bea-8550-c61f2cf0de81/dcop_a_130440_f0005_c.jpg)