Serum levels of IGFBP7 are elevated during acute exacerbation in COPD patients

Figures & data

Table 1 Baseline characteristics of the subjects of the first group

	AECOPD in ICU (n=11)	AECOPD not in ICU (n=14)	Healthy control (n=29)	P-value
Age (years) mean ± SD	77.64±8.52	78.36±3.95	75±5.8	0.623
Men:women	7:4	11:3	21:8	0.585
Ever-smoker (n, %)	8 (73)	11 (79)	21 (73)	0.564
PaCO2 (mmHg) mean ± SD	80.09±8.42	55.93±7.1	NA	NA
Hospital stay	NA	13.5±10.0	NA	NA
IGFBP7 (ng/mL) mean ± SD	52.92±16.32	40.66±13.90	30.03±7.09	P<0.01

Abbreviations: AECOPD, acute exacerbation of chronic obstructive pulmonary disease; ICU, intensive care unit; IGFBP7, insulin-like growth factor binding protein 7; NA, not applicable.

Table 2 Characteristics of the AECOPD subjects in the second group

n	22
Age (years)	74.3±7.75
Sex (male:female)	18:4
Ever-smoker, n	16
CRP (mg/L)	42.6±43.27
PCT (µg/L)	0.47±1.19
WBC (10^9/L)	6.68±2.59
N (10^9/L)	5.16±2.66
PaO2/FiO2	236.68±65.97
PaCO2 (mmHg)	50.61±14.53
Hospital stay (days)	8.91±4.99
IGFBP7 (ng/mL)	34.42±11.88

Note: Data shown as mean ± SD unless otherwise indicated.

Abbreviations: AECOPD, acute exacerbation of chronic obstructive pulmonary disease; CRP, C-reactive protein; PCT, procalcitonin; WBC, white blood cell count; N, neutrophil%; IGFBP7, insulin-like growth factor binding protein 7.

Figure 1 Serum IGFBP7 concentrations in patients with AECOPD in ICU, not in ICU, and healthy control subjects in the first group.

Abbreviations: AECOPD, acute exacerbation of chronic obstructive pulmonary disease; IGFBP7, insulin-like growth factor binding protein 7; ICU, intensive care unit.

Figure 2 Serum IGFBP7 and CRP concentrations during exacerbations and after clinical improvement in AECOPD patients in the second group.

Notes: (A) Comparison of IGFBP7 level; (B) comparison of CRP level; (C) change of IGFBP7 level during exacerbations and after clinical improvement in 20 AECOPD patients; (D) change of CRP level during exacerbations and after clinical improvement in 20 AECOPD patients.
Abbreviations: AECOPD, acute exacerbation of chronic obstructive pulmonary disease; IGFBP7, insulin-like growth factor binding protein 7; ICU, intensive care unit; CRP, C-reactive protein.

Figure 3 Correlation of serum IGFBP7 levels with CRP levels in patients with COPD exacerbations in the second group.

Notes: Spearman analysis was performed. r=0.357, P=0.123.
Abbreviations: IGFBP7, insulin-like growth factor binding protein 7; CRP, C-reactive protein; COPD, chronic obstructive pulmonary disease.

Figure 4 ROC curve for IGFBP7 and CRP in discrimination of AECOPD patients on the admission day and discharge day in the second group.

Abbreviations: IGFBP7, insulin-like growth factor binding protein 7; CRP, C-reactive protein; AECOPD, acute exacerbation of chronic obstructive pulmonary disease; ROC, receiver operating characteristic.