Advanced search
Publication Cover
International Journal of Chronic Obstructive Pulmonary Disease Volume 12, 2017 - Issue
Submit an article Journal homepage
57
Views
2
CrossRef citations to date
0
Altmetric
Original Research

Comparison of distinctive models for calculating an interlobar emphysema heterogeneity index in patients prior to endoscopic lung volume reduction

Dorothea Theilig1 Department of Radiology, Charité Campus Virchow Klinikum, Charité, Universitätsmedizin Berlin, Berlin, GermanyCorrespondence[email protected]
,
Felix Doellinger1 Department of Radiology, Charité Campus Virchow Klinikum, Charité, Universitätsmedizin Berlin, Berlin, Germany
,
Alexander Poellinger1 Department of Radiology, Charité Campus Virchow Klinikum, Charité, Universitätsmedizin Berlin, Berlin, Germany
,
Vera Schreiter1 Department of Radiology, Charité Campus Virchow Klinikum, Charité, Universitätsmedizin Berlin, Berlin, Germany
,
Konrad Neumann2 Institute of Biometrics and Clinical Epidemiology, Charité Campus Benjamin Franklin, Charité, Universitätsmedizin Berlin, Berlin, Germany
&
Ralf-Harto Hubner3 Department of Pneumology, Charité Campus Virchow Klinikum, Charité, Universitätsmedizin Berlin, Berlin, Germany
Pages 1631-1640 | Published online: 01 Jun 2017

Figures & data

Table 1 Descriptive statistics of the study population (n=50)

Figure 1 Coronary 3D surface view of a processed HRCT scan of the lung acquired in inspiration depicting the lung lobes (semitransparent green, lower lobes; semitransparent red, upper lobe; semitransparent blue, right middle lobe) and voxels with a density below −950 HU (orange).

Note: The calculated emphysema scores, that is, percentages of voxels below −950 HU in a lung lobe to the total number of voxels in that lobe, were as follows: right upper lobe 26.4%, right middle lobe 16.0%, right lower lobe 14.9%, left upper lobe 27.8%, and left lower lobe 4.9%.
Abbreviation: HRCT, high-resolution computed tomography.
Figure 1 Coronary 3D surface view of a processed HRCT scan of the lung acquired in inspiration depicting the lung lobes (semitransparent green, lower lobes; semitransparent red, upper lobe; semitransparent blue, right middle lobe) and voxels with a density below −950 HU (orange).

Table 2 Definitions of the six interlobar emphysema heterogeneity indices investigated in our study

Table 3 Overview of the major characteristics of the interlobar emphysema heterogeneity indices investigated in this study

Table 4 ROC curve analysis to determine the predictive accuracy of the different HIs with respect to FEV1 improvement after ELVR

Table 5 Critical values of the HI 6 and HI 4 with their respective sensitivity and specificity that can be considered to identify relevant emphysema heterogeneity with regard to the prediction of significant improvement in FEV1 after ELVR

Figure 2 ROC of all HIs.

Note: *1–2 flag the values closest to the upper left corner.
Abbreviations: HI, heterogeneity index; ROC, receiver-operating characteristic.
Figure 2 ROC of all HIs.

Table 6 ROC curve analysis of all patients with a tendency toward upper lobe predominant emphysema and upper lobe treatment (n=24) to determine the predictive accuracy of the different HIs with respect to FEV1 improvement after ELVR, assuming an increase in FEV1 of 100 mL to indicate MCID

Table 7 ROC curve analysis of all patients with a tendency toward lower lobe predominant emphysema and lower lobe treatment (n=38) to determine the predictive accuracy of the different HIs with respect to FEV1 improvement after ELVR, assuming an increase in FEV1 of 100 mL to indicate MCID

Figure 3 Receiver-operating characteristic of all patients with a tendency toward upper lobe predominant emphysema and upper lobe treatment (n=24).

Abbreviation: HI, heterogeneity index.

Figure 3 Receiver-operating characteristic of all patients with a tendency toward upper lobe predominant emphysema and upper lobe treatment (n=24).Abbreviation: HI, heterogeneity index.

Figure 4 Receiver-operating characteristic of all patients with a tendency toward lower lobe predominant emphysema and lower lobe treatment (n=38).

Abbreviation: HI, heterogeneity index.
Figure 4 Receiver-operating characteristic of all patients with a tendency toward lower lobe predominant emphysema and lower lobe treatment (n=38).

Table S1 ROC curve analysis of all patients (n=62) to determine the predictive accuracy of the different volume-weighted HIs (HI * targeted lobe volume) with respect to FEV1 increased after ELVR assuming an increase in FEV1 of 100 mL to indicate MCID

Table S2 Definitions of the additional HIs calculated from the TAR

Table S3 ROC curve analysis of all patients (n=62) to determine the predictive accuracy of HIs calculated from the TAR with respect to FEV1 change after ELVR assuming an increase of FEV1 of 100 mL to indicate MCID

Table S4 ROC curve analysis of all patients (n=62) to determine the predictive accuracy of the different HIs with respect to FEV1 improvement after ELVR assuming an increase in FEV1 of 100 mL to indicate MCID

Table S5 ROC curve analysis of all patients with available 6MWT results (n=44) to determine the predictive accuracy of the different HIs with respect to 6MWT improvement after ELVR, assuming an increase in 6MWT of 26 minutes to indicate MCID

Table S6 ROC curve analysis of all patients with available SGRQ test results (n=47) to determine the predictive accuracy of the different HIs with respect to SGRQ improvement after ELVR, assuming an increase in SGRQ of 4 units to indicate MCID

Table S7 ROC curve analysis of all patients (n=62) to determine the predictive accuracy of the different HIs with respect to RV reduction after ELVR, assuming a decrease in RV of 0.31 L to indicate MCID

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.