Genetic polymorphism and chronic obstructive pulmonary disease

Figures & data

Table 1 Genes involved in pathogenesis of COPD

Genome-wide association study	4q31 near HHIP, 15q25 near CHRNA5, 4q13 near SHOWAHB, 8q24 near TRAPPC9, 10p12 near KIAA1462, CHRNA3, PSMA4 and ADAMTS7 in 15q25 region
Single gene polymorphism	Oxidation–antioxidation system	Glutathione S-transferase Microsomal epoxide hydrolase Heme oxygenase Superoxide dismutase
	Hydrolytic–antihydrolytic system	Serine protease inhibitor 1 Serine protease inhibitor 2 SERPINA3 Matrix metalloproteinase Lyase-metalloprotease 33
	Inflammatory mediator	Vitamin D binding protein Transforming growth factor-β1 Tumor necrosis factor
	Other	β2-adrenergic receptor
Epigenetic inheritance	Regulation of DNA methylation, histone acetylation and miRNA, KANSL1
Apoptosis	B cell CLL/lymphoma 2 (Bcl-2) family protein

Abbreviations: COPD, chronic obstructive pulmonary disease; miRNA, microRNA; TRAPPC9, trafficking protein particle complex 9.