Comparative Effectiveness Of Fluoroquinolone Antibiotic Use In Uncomplicated Acute Exacerbations Of COPD: A Multi-Cohort Study

Figures & data

Table 1 Frequency Of Antibiotics Used For Initial Treatment Of Acute Exacerbations Of COPD

Antibiotic	Count	Percent
Clarithromycin	54,292	20.2%
Azithromycin	48,992	18.2%
Amoxicillin	38,376	14.3%
Moxifloxacin	27,829	10.3%
Doxycycline	21,749	8.1%
Levofloxacin	19,254	7.2%
Cefuroxime	14,971	5.6%
Amoxicillin/Clavulanate	10,366	3.9%
Ciprofloxacin	8088	3.0%
Cephalexin	6975	2.6%

Table 2 Crude Outcome Event Rates (%) Among AECOPD Treated With A Fluoroquinolone Compared With Other Antibiotics

Province	Repeat Ambulatory Care Visit For AECOPD		Hospitalisation For AECOPD		Subsequent Antibiotic Dispensation
	FQ	Other AB	FQ	Other AB	FQ	Other AB
Alberta	24.5	17.7	3.25	1.79	16.8	16.3
British Columbia	26.0	19.8	1.63	0.65	16.8	16.1
Manitoba	23.8	15.9	2.05	0.91	17.0	15.1
Nova Scotia	30.9	22.1	2.47	1.22	17.7	15.1
Ontario	22.7	17.4	3.23	1.98	16.7	16.7
Saskatchewan	27.3	17.2	4.43	1.35	19.1	16.1

Abbreviations: AB, antibiotics; AECOPD, acute exacerbation of chronic obstructive pulmonary disease; FQ, fluoroquinolones.

Figure 1 Flow chart for study cohort creation.

Note: Patients were allowed to enter the cohort multiple times with a new AECOPD event.
Abbreviation: AECOPD, acute exacerbation of chronic obstructive pulmonary disease.

Figure 2 ORs (95% CI) for repeat ambulatory care visits associated with AECOPD initially treated with a fluoroquinolone compared with other antibiotics.

Abbreviations: AB, antibiotics; AECOPD, acute exacerbation of chronic obstructive pulmonary disease; CI, confidence interval; FQ, fluoroquinolones; OR, odds ratio; SE, standard error; IV, inverse variance.

Figure 3 ORs (95% CI) for hospitalisations associated with AECOPD initially treated with a fluoroquinolone compared with other antibiotics.

Abbreviations: AB, antibiotics; AECOPD, acute exacerbation of chronic obstructive pulmonary disease; CI, confidence interval; FQ, fluoroquinolones; OR, odds ratio; SE, standard error; IV, inverse variance.

Figure 4 ORs (95% CI) for subsequent antibiotic dispensations associated with AECOPD initially treated with a fluoroquinolone compared with other antibiotics.

Abbreviations: AB, antibiotics; AECOPD, acute exacerbation of chronic obstructive pulmonary disease; CI, confidence interval; FQ, fluoroquinolones; OR, odds ratio; SE, standard error; IV, inverse variance.