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International Journal of Chronic Obstructive Pulmonary Disease Volume 14, 2019 - Issue
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Original Research

Mixed Phenotype of Emphysema and Airway Wall Thickening Is Associated with Frequent Exacerbation in Chronic Obstructive Pulmonary Disease Patients

Jeong Uk Lim1 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South KoreaORCID Iconhttps://orcid.org/0000-0001-8364-2380
ORCID Icon,
Eun Kyung Kim2 Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, South KoreaORCID Iconhttps://orcid.org/0000-0001-6239-1682
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Seong Yong Lim3 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South KoreaORCID Iconhttps://orcid.org/0000-0001-8098-3622
ORCID Icon,
Jin Hwa Lee4 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, South KoreaORCID Iconhttps://orcid.org/0000-0003-0843-9862
ORCID Icon,
Jae Seung Lee5 Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaORCID Iconhttps://orcid.org/0000-0003-4130-1486
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Sang-Do Lee5 Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
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Yeon-Mok Oh5 Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaORCID Iconhttps://orcid.org/0000-0003-0116-4683
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Chin Kook Rhee1 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South KoreaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4533-7937
ORCID Icon & On behalf of the KOLD Study Group show all
Pages 3035-3042 | Published online: 30 Dec 2019

Figures & data

Table 1 Comparisons of Characteristics Among Four Computed Tomography-Based Phenotypes in 435 Patients with Chronic Obstructive Pulmonary Disease

Table 2 Comparison of Mortality Risk Between the Different Types (Log Rank Test)

Figure 1 Overall survival was compared between the four CT-defined phenotypes. Kaplan–Meier curve analyses indicated significant differences among groups (P=0.002).

Figure 1 Overall survival was compared between the four CT-defined phenotypes. Kaplan–Meier curve analyses indicated significant differences among groups (P=0.002).

Table 3 Association of Patient Factors with Severe Exacerbations Frequency During 1st Post-enrolment Year

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