Figures & data
![](/cms/asset/d7645ff3-d381-479f-b029-6c2bc267cd42/dcop_a_12198166_uf0001_b.jpg)
Figure 1 Circadian variation of COPD symptoms: *p<0.001 versus “midday”, “afternoon”, “evening”, “night” and “difficult to say” groups; p=0.006 versus “no particular time of day” (all COPD patients); †p<0.001 versus “midday”. Patient insight into the impact of chronic obstructive pulmonary disease in the morning: an internet survey. Partridge MR, Karlsson N, Small IR, et al. Curr Med Res Opin. 2009;25:2043–2048. Informa UK Ltd, trading as Taylor & Francis Group, reprinted by permission of the publisher (Taylor & Francis Ltd, http://www.tandfonline.com).Citation4
![Figure 1 Circadian variation of COPD symptoms: *p<0.001 versus “midday”, “afternoon”, “evening”, “night” and “difficult to say” groups; p=0.006 versus “no particular time of day” (all COPD patients); †p<0.001 versus “midday”. Patient insight into the impact of chronic obstructive pulmonary disease in the morning: an internet survey. Partridge MR, Karlsson N, Small IR, et al. Curr Med Res Opin. 2009;25:2043–2048. Informa UK Ltd, trading as Taylor & Francis Group, reprinted by permission of the publisher (Taylor & Francis Ltd, http://www.tandfonline.com).Citation4](/cms/asset/1556e98e-7117-4f89-9775-7489def70487/dcop_a_12198166_f0001_b.jpg)
Table 1 Tools to Assess COPD Symptoms Referring to Daily Variability
Table 2 Charactestistics of the Main Trial Reported by the Board