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International Journal of Chronic Obstructive Pulmonary Disease Volume 15, 2020 - Issue
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Original Research

Absence of Adverse Effects of Tiotropium/Olodaterol Compared with the Monocomponents on Long-Term Heart Rate and Blood Pressure in Patients with Moderate-to-Very-Severe COPD

Stefan Andreas1 Department of Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany;2 LungClinic Immenhausen, Immenhausen, Germany, Member of the German Center for Lung Research (DZL)Correspondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3918-6909
ORCID Icon,
Lorcan McGarvey3 Queen’s University Belfast, Belfast, UK
,
Ulrich Bothner4 Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany
,
Matthias Trampisch4 Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany
,
Alberto de la Hoz4 Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany
,
Matjaz Fležar5 Klinika Golnik, Golnik, Slovenia
,
Roland Buhl6 Pulmonary Department, Johannes Gutenberg University Mainz, Mainz, Germany
&
Peter Alter7 Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg (UMR), Marburg, Germany, Member of the German Center for Lung Research (DZL)ORCID Iconhttps://orcid.org/0000-0002-2115-1743
ORCID Icon show all
Pages 1935-1944 | Published online: 10 Aug 2020

Figures & data

Table 1 Demographic and Baseline Patient Characteristics by Treatment Group for the 52-Week, Parallel-Group Trials (Treated Patient Population)

Figure 1 Long-term mean change in HR from baseline over 52 weeks. *P<0.05. Error bars representing 95% confidence interval.

Abbreviations: bpm, beats per minute; HR, heart rate; Olo, olodaterol; T/O, tiotropium/olodaterol; Tio, tiotropium.
Figure 1 Long-term mean change in HR from baseline over 52 weeks. *P<0.05. Error bars representing 95% confidence interval.

Figure 2 Short-term (30 minutes pre- to 40 minutes post-dose) mean change in HR during dosing over 52 weeks. **P<0.01. Error bars representing 95% confidence interval.

Abbreviations: bpm, beats per minute; HR, heart rate; Olo, olodaterol; T/O, tiotropium/olodaterol; Tio, tiotropium.
Figure 2 Short-term (30 minutes pre- to 40 minutes post-dose) mean change in HR during dosing over 52 weeks. **P<0.01. Error bars representing 95% confidence interval.

Figure 3 Long-term mean change in (A) systolic and (B) diastolic BP from baseline over 52 weeks. *P<0.05; **P<0.01. Error bars representing 95% confidence interval.

Abbreviations: BP, blood pressure; Olo, olodaterol; T/O, tiotropium/olodaterol; Tio, tiotropium.
Figure 3 Long-term mean change in (A) systolic and (B) diastolic BP from baseline over 52 weeks. *P<0.05; **P<0.01. Error bars representing 95% confidence interval.

Figure 4 Short-term (1 hour pre- to 1 hour post-dose) mean change in (A) systolic and (B) diastolic BP during dosing over 52 weeks. *P<0.05. Error bars representing 95% confidence interval.

Abbreviations: BP, blood pressure; Olo, olodaterol; T/O, tiotropium/olodaterol; Tio, tiotropium.
Figure 4 Short-term (1 hour pre- to 1 hour post-dose) mean change in (A) systolic and (B) diastolic BP during dosing over 52 weeks. *P<0.05. Error bars representing 95% confidence interval.

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