Towards Personalized Management of Sarcopenia in COPD

Figures & data

Figure 1 Pathophysiology of sarcopenia in COPD: Age and COPD can be considered as initial determinants of disease specific and shared triggers (in blue) that initiate independent and interrelated pathophysiological mechanisms through alterations of multiple muscle cell signaling pathways (which have been discussed extensively by other authors such as Langen et al³⁶ and Abdulai et al³⁷). Eventually these converge on and deregulate three key processes (in orange) responsible for muscle homeostasis, leading to sarcopenia.

Langen RC, Gosker HR, Remels AH, Schols AM. Triggers and mechanisms of skeletal muscle wasting in chronic obstructive pulmonary disease. Int J Biochem Cell Biol. 2013;45(10):2245–2256. doi:10.1016/j.biocel.2013.06.015

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Abdulai RM, Jensen TJ, Patel NR, et al. Deterioration of limb muscle function during acute exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2018;197(4):433–449. doi:10.1164/rccm.201703-0615CI

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