Molecular and Clinicopathological Characteristics of Lung Cancer Concomitant Chronic Obstructive Pulmonary Disease (COPD)

Figures & data

Table 1 Clinicopathological Characteristics of the Chinese Cohort

Characteristic	COPD	Non-COPD	P value
	No. of Patients (%)	No. of Patients (%)
Total of patients	51(100)	88(100)
Age (yr)			P<0.001
Mean±SD	73.1±8.0	66.1±10.6
Sex - no. (%)			P<0.001
Male	40(78)	42(48)
Female	11(22)	46(52)
Pathology - no. (%)			P=0.087
Adenocarcinoma	32(63)	71(81)
Squamous-cell carcinoma	12(23)	13(15)
Adenosquamous carcinoma	2(4)	1(1)
Others	5(10)	3(3)
Stage - no. (%)			P=0.142
I	2(4)	7(8)
II	2(4)	2(2)
III	12(23)	8(9)
IV	34(67)	67(76)
NA	1(2)	4(5)
Smoking history - no. (%)			P=0.002
Yes	29(57)	36(41)
No	18(35)	52(59)
NA	4(8)	0(0)

Figure 1 Analysis of our Chinese cohort. (A) Heatmap of 539 cancer related genes mutation of COPD-LC (n = 21) and non-COPD-LC (n = 68) in our Chinese cohort. (B) Comparison of differential mutation genes displayed within COPD-LC and non-COPD-LC. (C) Comparison of TMB within COPD-LC and non-COPD-LC. (D) Relationship of differential mutation genes and TMB in COPD-LC (LRP1B and PREX2). (E) PD-L1 expression status with COPD-LC and non-COPD-LC. Notes: *P < 0.05; **P < 0.01; ***P <0.001.

Figure 2 Survival analysis of EGFR mutant patients with EGFR-TKI treatment. (A) Kaplan–Meier curves of PFS in EGFR mutant COPD-LC and non-COPD-LC patients. (B) Multivariate Cox regression analysis of EGFR mutant patients with EGFR-TKI treatment.

Figure 3 Analysis of TCGA cohort. (A) Heatmap of 539 cancer related genes mutation of COPD-LC (n = 69) and non-COPD-LC (n = 126) in TCGA cohort. (B) Comparison of differential mutation genes displayed within COPD-LC and non-COPD-LC. (C) Comparison of TMB within COPD-LC and non-COPD-LC. (D) Boxplot depicting the infiltration of 22 immune cells in COPD-LC and non-COPD-LC. CIBERSORT was used to calculate the infiltration degree of these immune cells. (E) Differences in pathway activities scored by GSEA Hallmark collection between COPD-LC and non-COPD-LC. Enrichment results with significant associations between COPD-LC and non-COPD-LC are shown (P < 0.05, FDR < 0.05). Notes: *P < 0.05; **P < 0.01; ****P < 0.0001.