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ORIGINAL RESEARCH

Effect of Macrolide Antibiotics on In-Hospital Mortality Among Acute Exacerbation of COPD Patients: A Propensity Score-Matched Analysis

ORCID Icon, ORCID Icon & ORCID Icon
Pages 2229-2239 | Received 11 May 2022, Accepted 28 Aug 2022, Published online: 13 Sep 2022

Figures & data

Table 1 Comparison of Baseline Characteristics, Admission Parameters, and Year of Hospitalization Between Macrolide and Non-Macrolide Groups: Original Cohort (n = 1882) and Propensity-Matched Cohort (n = 1528). All Admission Records of AECOPD Patients Between October 2015 and September 2018

Table 2 Macrolides and Other Antibiotic Co-Administrations and Systemic Steroids

Figure 1 Study flow chart of all AECOPD patients admitted to the medical general ward and medical intensive care unit.

Notes: The diagnosis of AECOPD was based on ICD-10 codes J44.0, J44.1, and J44.9 as the principal diagnoses in the admission records.
Abbreviations: AECOPD, acute exacerbation of chronic obstructive pulmonary disease; FEV1, forced expiratory volume-one second; FVC, forced vital capacity; ED, emergency department; PS, propensity score.
Figure 1 Study flow chart of all AECOPD patients admitted to the medical general ward and medical intensive care unit.

Table 3 Logistic Regression Models for the Derivation of the Propensity Score

Table 4 Microbiological Results Including Sputum and Tracheal Aspiration Cultures of Hospitalized Acute Exacerbation of COPD Patients in Propensity-Matched Cohort (n = 1092 Admissions)

Figure 2 Kaplan–Meier survival curve shows the impact on in-hospital mortality of macrolide treatment.

Figure 2 Kaplan–Meier survival curve shows the impact on in-hospital mortality of macrolide treatment.

Figure 3 Risk of in-hospital mortality by subgroups of culture results in patients treated with macrolides vs non-macrolides.

Figure 3 Risk of in-hospital mortality by subgroups of culture results in patients treated with macrolides vs non-macrolides.