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ORIGINAL RESEARCH

History of Respiratory Events Prior to a First COPD Diagnosis and Future Exacerbations: A Longitudinal Observational Cohort Database Study in Japan

Bo Ding1 BioPharmaceuticals Medical, AstraZeneca, Gothenburg, Sweden

https://orcid.org/0000-0001-9131-4563 View further author information

Rebecca Zaha2 Formerly of Data Analytics, Evidera, Bethesda, MD, USAView further author information

Naoyuki Makita3 Medical Department, AstraZeneca K.K, Kita-ku, Osaka, JapanView further author information

Sophie Graham4 Data Analytics, Evidera, London, UK;5 Epidemiology & Population Health, London School of Hygiene and Tropical Medicine, London, UKView further author information

Dimitra Lambrelli4 Data Analytics, Evidera, London, UK

https://orcid.org/0000-0002-2430-1778 View further author information

Samuel Huse6 Data Analytics, Evidera, Bethesda, MD, USAView further author information

Hana Müllerová7 BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK

https://orcid.org/0000-0002-0949-0101 View further author information

Clementine Nordon7 BioPharmaceuticals Medical, AstraZeneca, Cambridge, UKCorrespondence[email protected]

https://orcid.org/0000-0001-9441-9723 View further author information

Shigeo Muro8 Department of Respiratory Medicine, Nara Medical University, Nara, Japan

https://orcid.org/0000-0001-7452-9191 View further author information

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Figures & data

Figure 1 Study design.

Abbreviation: COPD, chronic obstructive pulmonary disease.

Table 1 Baseline Sociodemographics and Respiratory Medication in All Patients Newly Diagnosed with COPD (N = 20,212), and Patients Categorized According to Whether They Had at Least One Severe Respiratory Event During Baseline (N = 955) or Not (N = 19,257)

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Table 2 Baseline Comorbidities in All Patients Newly Diagnosed with COPD (N = 20,212), and Patients Categorized According to Whether They Had at Least One Severe Respiratory Event During Baseline (N = 955) or Not (N = 19,257)

Download CSV Display Table

Figure 2 Patient selection and flow chart.

Abbreviation: COPD, chronic obstructive pulmonary disease.

Table 3 Frequency and Incidence of AECOPD^a (Any, Moderate and Severe) During Follow-Up in All Patients (N = 20,212) and Patients Categorized According to Whether They Had at Least One Respiratory Event^b During Baseline (N = 955) or Not (N = 19,257)

Download CSV Display Table

Table 4 Risk Ratio of AECOPD^a (Any Severity) During Follow-Up in Association with Respiratory Event^b (vs None) Prior to a First COPD Diagnosis, Estimated by Negative Binomial Models in a Cohort of 20,212 Newly Diagnosed COPD Patients

Download CSV Display Table

History of Respiratory Events Prior to a First COPD Diagnosis and Future Exacerbations: A Longitudinal Observational Cohort Database Study in Japan

Table 1 Baseline Sociodemographics and Respiratory Medication in All Patients Newly Diagnosed with COPD (N = 20,212), and Patients Categorized According to Whether They Had at Least One Severe Respiratory Event During Baseline (N = 955) or Not (N = 19,257)

Table 2 Baseline Comorbidities in All Patients Newly Diagnosed with COPD (N = 20,212), and Patients Categorized According to Whether They Had at Least One Severe Respiratory Event During Baseline (N = 955) or Not (N = 19,257)

Table 3 Frequency and Incidence of AECOPD^a (Any, Moderate and Severe) During Follow-Up in All Patients (N = 20,212) and Patients Categorized According to Whether They Had at Least One Respiratory Event^b During Baseline (N = 955) or Not (N = 19,257)

Table 4 Risk Ratio of AECOPD^a (Any Severity) During Follow-Up in Association with Respiratory Event^b (vs None) Prior to a First COPD Diagnosis, Estimated by Negative Binomial Models in a Cohort of 20,212 Newly Diagnosed COPD Patients

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History of Respiratory Events Prior to a First COPD Diagnosis and Future Exacerbations: A Longitudinal Observational Cohort Database Study in Japan

Figures & data

Table 1 Baseline Sociodemographics and Respiratory Medication in All Patients Newly Diagnosed with COPD (N = 20,212), and Patients Categorized According to Whether They Had at Least One Severe Respiratory Event During Baseline (N = 955) or Not (N = 19,257)

Table 2 Baseline Comorbidities in All Patients Newly Diagnosed with COPD (N = 20,212), and Patients Categorized According to Whether They Had at Least One Severe Respiratory Event During Baseline (N = 955) or Not (N = 19,257)

Table 3 Frequency and Incidence of AECOPDa (Any, Moderate and Severe) During Follow-Up in All Patients (N = 20,212) and Patients Categorized According to Whether They Had at Least One Respiratory Eventb During Baseline (N = 955) or Not (N = 19,257)

Table 4 Risk Ratio of AECOPDa (Any Severity) During Follow-Up in Association with Respiratory Eventb (vs None) Prior to a First COPD Diagnosis, Estimated by Negative Binomial Models in a Cohort of 20,212 Newly Diagnosed COPD Patients

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Table 3 Frequency and Incidence of AECOPD^a (Any, Moderate and Severe) During Follow-Up in All Patients (N = 20,212) and Patients Categorized According to Whether They Had at Least One Respiratory Event^b During Baseline (N = 955) or Not (N = 19,257)

Table 4 Risk Ratio of AECOPD^a (Any Severity) During Follow-Up in Association with Respiratory Event^b (vs None) Prior to a First COPD Diagnosis, Estimated by Negative Binomial Models in a Cohort of 20,212 Newly Diagnosed COPD Patients