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International Journal of Chronic Obstructive Pulmonary Disease Volume 18, 2023 - Issue
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ORIGINAL RESEARCH

Blood Eosinophils and Clinical Outcomes in Inpatients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study

Jiaqi Pu1 Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaView further author information
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Qun Yi1 Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of China;2 Sichuan Cancer Hospital and Institution, Sichuan Cancer Center, Cancer Hospital Affiliate to School of Medicine, UESTC, Chengdu, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-3302-9139View further author information
ORCID Icon,
Yuanming Luo3 State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaView further author information
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Hailong Wei4 Department of Respiratory and Critical Care Medicine, People’s Hospital of Leshan, Leshan, People’s Republic of ChinaView further author information
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Huiqing Ge5 Department of Respiratory and Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of ChinaView further author information
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Huiguo Liu6 Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaView further author information
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Xianhua Li7 Department of Respiratory and Critical Care Medicine, the First People’s Hospital of Neijiang City, Neijiang, People’s Republic of ChinaView further author information
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Jianchu Zhang8 Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaView further author information
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Pinhua Pan9 Department of Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, People’s Republic of ChinaView further author information
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Hui Zhou10 Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Chengdu University, Chengdu, People’s Republic of ChinaView further author information
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Chen Zhou11 West China School of Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaView further author information
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Mengqiu Yi12 Department of Emergency, First People’s Hospital of Jiujiang, Jiu Jiang, People’s Republic of ChinaView further author information
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Lina Cheng12 Department of Emergency, First People’s Hospital of Jiujiang, Jiu Jiang, People’s Republic of ChinaView further author information
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Liang Liu10 Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Chengdu University, Chengdu, People’s Republic of ChinaView further author information
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Jiarui Zhang1 Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaView further author information
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Lige Peng1 Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-3324-053XView further author information
ORCID Icon,
Adila Aili1 Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaView further author information
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Yu Liu1 Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaView further author information
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Haixia Zhou1 Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaCorrespondence[email protected]
View further author information
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Pages 169-179 | Received 13 Nov 2022, Accepted 15 Feb 2023, Published online: 28 Feb 2023

Figures & data

Figure 1 Flow chart of the study.

Abbreviations: AECOPD, acute exacerbation of chronic obstructive pulmonary disease; EOS, eosinophils.
Figure 1 Flow chart of the study.

Table 1 Baseline Characteristics of the Study Population

Table 2 Laboratory Tests Between Eosinophilic and Non-Eosinophilic Groups

Table 3 Clinical Outcomes in the Study Populations

Figure 2 Clinical outcomes in the study populations ((A–D) Show clinical outcomes in the total patients and subgroups with pneumonia, respiratory failure, and ICU admission, respectively. *P value < 0.05.).

Abbreviations: ICU, intensive care unit; EOS, eosinophils.
Figure 2 Clinical outcomes in the study populations ((A–D) Show clinical outcomes in the total patients and subgroups with pneumonia, respiratory failure, and ICU admission, respectively. *P value < 0.05.).

Figure 3 Risk of in-hospital mortality in different study populations with eosinophilic and non-eosinophilic AECOPD.

Abbreviations: AECOPD, acute exacerbation of chronic obstructive pulmonary disease; ICU, intensive care unit; HR, hazard ratio; CI, confidence interval.
Figure 3 Risk of in-hospital mortality in different study populations with eosinophilic and non-eosinophilic AECOPD.

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