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International Journal of Chronic Obstructive Pulmonary Disease Volume 18, 2023 - Issue
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REVIEW

NT-proBNP in Different Patient Groups of COPD: A Systematic Review and Meta-Analysis

Xiaojie Su1 The First Clinical Medical College of Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China;2 Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of ChinaView further author information
,
Ting Lei1 The First Clinical Medical College of Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China;2 Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of ChinaView further author information
,
Haichuan Yu1 The First Clinical Medical College of Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China;2 Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-4231-2542View further author information
ORCID Icon,
Lu Zhang1 The First Clinical Medical College of Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China;2 Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of ChinaView further author information
,
Zhouzhou Feng1 The First Clinical Medical College of Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China;2 Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of ChinaView further author information
,
Tiankui Shuai1 The First Clinical Medical College of Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China;2 Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of ChinaView further author information
,
Hong Guo1 The First Clinical Medical College of Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China;2 Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of ChinaView further author information
&
Jian Liu1 The First Clinical Medical College of Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China;2 Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1825-571XView further author information
ORCID Icon show all
Pages 811-825 | Received 31 Jan 2023, Accepted 29 Apr 2023, Published online: 10 May 2023

Figures & data

Figure 1 Flowchart of information through the different phases of this systematic review and meta-analysis.

Abbreviation: BNP, brain natriuretic peptide.
Figure 1 Flowchart of information through the different phases of this systematic review and meta-analysis.

Figure 2 Forest plot of NT-proBNP level between COPD patients and Non-COPD patients.

Abbreviations: NT-proBNP, amino-terminal pro-brain natriuretic peptide; COPD, chronic obstructive pulmonary disease; SMD, standardized mean difference; CI, Confidence Interval; SD, Standard Deviation.
Figure 2 Forest plot of NT-proBNP level between COPD patients and Non-COPD patients.

Figure 3 Forest plot of NT-proBNP level between COPD patients and Non-COPD patients subgroups.

Abbreviations: NT-proBNP, amino-terminal pro-brain natriuretic peptide; COPD, chronic obstructive pulmonary disease; SMD, standardized mean difference; CI, Confidence Interval; SD, Standard Deviation.
Figure 3 Forest plot of NT-proBNP level between COPD patients and Non-COPD patients subgroups.

Figure 4 Sensitivity analysis plot of NT-proBNP level between COPD patients and Non-COPD patients.

Abbreviations: NT-proBNP, amino-terminal pro-brain natriuretic peptide; COPD, chronic obstructive pulmonary disease; SMD, standardized mean difference; CI, Confidence Interval; SD, Standard Deviation.
Figure 4 Sensitivity analysis plot of NT-proBNP level between COPD patients and Non-COPD patients.

Figure 5 Forest plot of NT-proBNP level between stable COPD patients and healthy control.

Abbreviations: NT-proBNP, amino-terminal pro-brain natriuretic peptide; COPD, chronic obstructive pulmonary disease; SCOPD, stable chronic obstructive pulmonary disease; SMD, standardized mean difference; CI, Confidence Interval; SD, Standard Deviation.
Figure 5 Forest plot of NT-proBNP level between stable COPD patients and healthy control.

Figure 6 Sensitivity analysis plot of NT-proBNP level between COPD patients and healthy control.

Abbreviations: NT-proBNP, amino-terminal pro-brain natriuretic peptide; COPD, chronic obstructive pulmonary disease; SCOPD, stable chronic obstructive pulmonary disease; SMD, standardized mean difference; CI, Confidence Interval; SD, Standard Deviation.
Figure 6 Sensitivity analysis plot of NT-proBNP level between COPD patients and healthy control.

Figure 7 Forest plot of NT-proBNP level between stable COPD patients and AECOPD patients.

Abbreviations: NT-proBNP, amino-terminal pro-brain natriuretic peptide; COPD, chronic obstructive pulmonary disease; AECOPD, acute exacerbation of chronic obstructive pulmonary disease; SCOPD, stable chronic obstructive pulmonary disease; SMD, standardized mean difference; CI, Confidence Interval; SD, Standard Deviation.
Figure 7 Forest plot of NT-proBNP level between stable COPD patients and AECOPD patients.

Figure 8 Sensitivity analysis plot of NT-proBNP level between stable COPD patients and AECOPD patients.

Abbreviations: NT-proBNP, amino-terminal pro-brain natriuretic peptide; COPD, chronic obstructive pulmonary disease; AECOPD, acute exacerbation of chronic obstructive pulmonary disease; SCOPD, stable chronic obstructive pulmonary disease; SMD, standardized mean difference; CI, Confidence Interval; SD, Standard Deviation.
Figure 8 Sensitivity analysis plot of NT-proBNP level between stable COPD patients and AECOPD patients.

Figure 9 Forest plot of NT-proBNP level between Severe group and Non-severe group.

Abbreviations: NT-proBNP, amino-terminal pro-brain natriuretic peptide; COPD, chronic obstructive pulmonary disease; SMD, standardized mean difference; CI, Confidence Interval; SD, Standard Deviation.
Figure 9 Forest plot of NT-proBNP level between Severe group and Non-severe group.

Figure 10 Forest plot of NT-proBNP level between Survivors and Non-survivors during hospitalisation.

Abbreviations: NT-proBNP, amino-terminal pro-brain natriuretic peptide; COPD, chronic obstructive pulmonary disease; SMD, standardized mean difference; CI, Confidence Interval; SD, Standard Deviation.
Figure 10 Forest plot of NT-proBNP level between Survivors and Non-survivors during hospitalisation.

Figure 11 Sensitivity analysis plot of NT-proBNP level between Survivors and Non-survivors.

Abbreviations: NT-proBNP, amino-terminal pro-brain natriuretic peptide; COPD, chronic obstructive pulmonary disease; SMD, standardized mean difference; CI, Confidence Interval; SD, Standard Deviation.
Figure 11 Sensitivity analysis plot of NT-proBNP level between Survivors and Non-survivors.

Figure 12 Forest plot of NT-proBNP level between COPD with CHF patients and COPD patients.

Abbreviations: NT-proBNP, amino-terminal pro-brain natriuretic peptide; COPD, chronic obstructive pulmonary disease; CHF, chronic heart failure; SMD, standardized mean difference; CI, Confidence Interval; SD, Standard Deviation.
Figure 12 Forest plot of NT-proBNP level between COPD with CHF patients and COPD patients.

Figure 13 Sensitivity analysis plot of NT-proBNP level between COPD with CHF patients and COPD patients.

Abbreviations: NT-proBNP, amino-terminal pro-brain natriuretic peptide; COPD, chronic obstructive pulmonary disease; CHF, chronic heart failure; SMD, standardized mean difference; CI, Confidence Interval; SD, Standard Deviation.
Figure 13 Sensitivity analysis plot of NT-proBNP level between COPD with CHF patients and COPD patients.

Figure 14 Forest plot of NT-proBNP level between CHF with COPD patients and CHF patients.

Abbreviations: NT-proBNP, amino-terminal pro-brain natriuretic peptide; CHF, chronic heart failure; COPD, chronic obstructive pulmonary disease; SMD, standardized mean difference; CI, Confidence Interval; SD, Standard Deviation.
Figure 14 Forest plot of NT-proBNP level between CHF with COPD patients and CHF patients.

Figure 15 Sensitivity analysis plot of NT-proBNP level between CHF with COPD patients and CHF patients.

Abbreviations: NT-proBNP, amino-terminal pro-brain natriuretic peptide; CHF, chronic heart failure; COPD, chronic obstructive pulmonary disease; SMD, standardized mean difference; CI, Confidence Interval; SD, Standard Deviation.
Figure 15 Sensitivity analysis plot of NT-proBNP level between CHF with COPD patients and CHF patients.

Figure 16 Forest plot of NT-proBNP level between COPD with PH patients and COPD patients.

Abbreviations: NT-proBNP, amino-terminal pro-brain natriuretic peptide; COPD, chronic obstructive pulmonary disease; PH, pulmonary hypertension; SMD, standardized mean difference; CI, Confidence Interval; SD, Standard Deviation.
Figure 16 Forest plot of NT-proBNP level between COPD with PH patients and COPD patients.

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