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International Journal of Chronic Obstructive Pulmonary Disease Volume 18, 2023 - Issue
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POSTER EXTRACTS

Clinical Implications of Peak Inspiratory Flow in COPD: Post Hoc Analyses of the TRONARTO Study

Donald A Mahler1 Geisel School of Medicine at Dartmouth, Hanover, NH, USA;2 Valley Regional Hospital, Claremont, NH, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-6332-4895
ORCID Icon,
Henrik Watz3 Pulmonary Research Institute at LungenClinic Grosshansdorf, Grosshansdorf, Germany
,
Rachel Emerson-Stadler4 Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany
,
John Ritz5 Syneos Health, Somerset, NJ, USA
,
Asparuh Gardev4 Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany
,
Asif Shaikh6 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USAORCID Iconhttps://orcid.org/0000-0002-5116-9338
ORCID Icon &
M Bradley Drummond7 Pulmonary Diseases and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAORCID Iconhttps://orcid.org/0000-0002-6968-4610
ORCID Icon show all
Pages 1729-1740 | Received 10 Jan 2023, Accepted 24 Jul 2023, Published online: 10 Aug 2023

Figures & data

Figure 1 Patient subgroups based on self-measured PIF readings.

Note: Data from Mahler et al.Citation18
Abbreviation: PIF, peak inspiratory flow.
Figure 1 Patient subgroups based on self-measured PIF readings.

Figure 2 (a) overall distribution of PIF values and (b) range between highest and lowest PIF value (by PIF subgroup based upon self-measured PIF readings over 28 days).

Note: Data from Mahler et al.Citation18
Abbreviation: PIF, peak inspiratory flow.
Figure 2 (a) overall distribution of PIF values and (b) range between highest and lowest PIF value (by PIF subgroup based upon self-measured PIF readings over 28 days).

Table 1 Trend Analysis for Baseline Characteristics Across the PIF Range Quartiles

Figure 3 Difference in PIF between at-home and in-clinic visits.a

Notes: aA single measurement was taken in the clinic and a mean value for the respective week at home (seven measurements per patient). Data from Mahler et al.Citation19 Error bars depict standard error.
Abbreviations: BL, baseline; PIF, peak inspiratory flow.
Figure 3 Difference in PIF between at-home and in-clinic visits.a

Figure 4 Mean PIF, weekly PIF range and variance (SE) in the overall population by study week.

Notes: Baseline PIF was measured in the clinic at first visit. Numbers in parentheses represent SE for both mean PIF and PIF range. At-home PIF measurements over respective weeks for each patient were used in the calculation of weekly PIF mean and range (difference between the highest and lowest PIF values). Data from Mahler et al.Citation19
Abbreviations: BL, baseline; PIF, peak inspiratory flow; SE, standard error.
Figure 4 Mean PIF, weekly PIF range and variance (SE) in the overall population by study week.

Table 2 Trend Analysis for Baseline Characteristics Across the PIF Subcategories

Figure 5 Correlation of PIF recorded at medium-low and high resistance.

Notes: Figure created using locally estimated scatterplot smoothing. Data from Drummond et al.Citation21
Abbreviation: PIF, peak inspiratory flow.
Figure 5 Correlation of PIF recorded at medium-low and high resistance.

Figure 6 Correlation of PIF with FVC and FEV1.

Notes: aPost-bronchodilator. Figure created using locally estimated scatterplot smoothing. Data from Drummond et al.Citation21
Abbreviations: FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; PIF, peak inspiratory flow.
Figure 6 Correlation of PIF with FVC and FEV1.

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