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International Journal of Chronic Obstructive Pulmonary Disease Volume 18, 2023 - Issue
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ORIGINAL RESEARCH

Comparison of Rescue Medication Prescriptions in Patients with Chronic Obstructive Pulmonary Disease Receiving Umeclidinium/Vilanterol versus Tiotropium Bromide/Olodaterol in Routine Clinical Practice in England

Gema Requena1 GSK, R&D Global Medical, Brentford, Middlesex, UKCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1889-6656View further author information
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Alexandrosz Czira1 GSK, R&D Global Medical, Brentford, Middlesex, UKORCID Iconhttps://orcid.org/0000-0002-3395-6186View further author information
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Victoria Banks2 Real-World Evidence, Adelphi Real World, Bollington, Cheshire, UKORCID Iconhttps://orcid.org/0000-0002-0087-7641View further author information
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Robert Wood2 Real-World Evidence, Adelphi Real World, Bollington, Cheshire, UKORCID Iconhttps://orcid.org/0000-0002-6977-435XView further author information
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Theo Tritton2 Real-World Evidence, Adelphi Real World, Bollington, Cheshire, UKView further author information
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Catherine M Castillo2 Real-World Evidence, Adelphi Real World, Bollington, Cheshire, UKORCID Iconhttps://orcid.org/0000-0002-7204-6169View further author information
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Jie Yeap2 Real-World Evidence, Adelphi Real World, Bollington, Cheshire, UKView further author information
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Rosie Wild2 Real-World Evidence, Adelphi Real World, Bollington, Cheshire, UKORCID Iconhttps://orcid.org/0000-0002-9963-6441View further author information
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Chris Compton1 GSK, R&D Global Medical, Brentford, Middlesex, UKORCID Iconhttps://orcid.org/0000-0002-7564-5343View further author information
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Kieran J Rothnie1 GSK, R&D Global Medical, Brentford, Middlesex, UKORCID Iconhttps://orcid.org/0000-0003-4279-1624View further author information
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Felix Herth3 Department of Pulmonology and Respiratory Care Medicine, Thoraxklinik at the University of Heidelberg, Heidelberg, Germany;4 Translational Lung Research Center Heidelberg, Member of the German Center for Lung Research DZL, Heidelberg, GermanyORCID Iconhttps://orcid.org/0000-0002-7638-2506View further author information
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Jennifer K Quint5 National Heart and Lung Institute, Imperial College London, London, UKORCID Iconhttps://orcid.org/0000-0003-0149-4869View further author information
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Afisi S Ismaila6 Value Evidence and Outcomes, GSK, Collegeville, PA, USA;7 Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, CanadaORCID Iconhttps://orcid.org/0000-0002-2876-8308View further author information
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Pages 1431-1444 | Received 07 Mar 2023, Accepted 03 Jul 2023, Published online: 13 Jul 2023

Figures & data

Figure 1 Study design. aThe first UMEC/VI or TIO/OLO prescription within the indexing period was defined as the index date. Only patients with no LAMA/LABA prescriptions prior to the index date were included in the analysis.

Abbreviations: LABA, long-acting β2-agonist; LAMA, long-acting muscarinic antagonist; OLO, olodaterol; TIO, tiotropium bromide; UMEC; umeclidinium; VI, vilanterol.
Figure 1 Study design. aThe first UMEC/VI or TIO/OLO prescription within the indexing period was defined as the index date. Only patients with no LAMA/LABA prescriptions prior to the index date were included in the analysis.

Figure 2 Sample attrition.

Abbreviations: COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in 1 second; FVC, forced volume capacity; GP, general practitioner; HES, Health Episode Statistics; ICS, inhaled corticosteroid; IND, indacaterol; LABA, long-acting β2-agonist; LAMA, long-acting muscarinic antagonist; OLO, olodaterol; TIO, tiotropium bromide; UMEC, umeclidinium; VI, vilanterol.
Figure 2 Sample attrition.

Table 1 Patient Demographics and Baseline Characteristics

Figure 3 (A) Mean number of rescue medication prescriptions between patients newly initiating UMEC/VI versus TIO/OLO in the 12 months following treatment initiation and (B) treatment differences for rescue medication prescriptions outcome in the ITT analysis.

Abbreviations: ATE, average treatment effect; CI, confidence interval; ITT, intention-to-treat; OLO, olodaterol; SD, standard deviation; TIO, tiotropium bromide; UMEC; umeclidinium; VI, vilanterol.
Figure 3 (A) Mean number of rescue medication prescriptions between patients newly initiating UMEC/VI versus TIO/OLO in the 12 months following treatment initiation and (B) treatment differences for rescue medication prescriptions outcome in the ITT analysis.

Figure 4 (A) Mean number of rescue medication prescriptions between patients newly initiating UMEC/VI versus TIO/OLO in the 6-, 18- and 24- months following treatment initiation and (B) Treatment differences for rescue medication prescriptions outcome in the ITT analysis.

Abbreviations: ATE, average treatment effect; CI, confidence interval; ITT, intention-to-treat; OLO, olodaterol; TIO, tiotropium bromide; UMEC; umeclidinium; VI, vilanterol.
Figure 4 (A) Mean number of rescue medication prescriptions between patients newly initiating UMEC/VI versus TIO/OLO in the 6-, 18- and 24- months following treatment initiation and (B) Treatment differences for rescue medication prescriptions outcome in the ITT analysis.

Table 2 Adherent Patients (PDC ≥80%) at 6-, 12-, 18- and 24-Months Post-Index Without Stockpiling

Table 3 Mean Number of Rescue Medication Prescriptions for Patients Newly Initiating UMEC/VI versus TIO/OLO in the 12 Months Following Treatment Initiation, Stratified by Adherence (PDC < 80%, PDC ≥ 80%), Without Stockpiling

Figure 5 Kaplan–Meier survival analysis for time to initiation of triple.

Abbreviations: CI, confidence interval; OLO, olodaterol; TIO, tiotropium bromide; UMEC; umeclidinium; VI, vilanterol.
Figure 5 Kaplan–Meier survival analysis for time to initiation of triple.

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