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International Journal of Chronic Obstructive Pulmonary Disease Volume 8, 2013 - Issue
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Original Research

Day-to-day measurement of patient-reported outcomes in exacerbations of chronic obstructive pulmonary disease

Jan Willem H Kocks1 Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands;2 Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
,
Jan Willem K van den Berg3 Department of Pulmonary Diseases, Isala Klinieken, Zwolle, The Netherlands
,
Huib AM Kerstjens2 Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands;4 Department of Pulmonary Diseases and Tuberculosis, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
,
Steven M Uil3 Department of Pulmonary Diseases, Isala Klinieken, Zwolle, The Netherlands
,
Judith M Vonk2 Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands;5 Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
,
Ynze P de Jong3 Department of Pulmonary Diseases, Isala Klinieken, Zwolle, The Netherlands
,
Ioanna G Tsiligianni1 Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands;2 Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen, Groningen, The NetherlandsCorrespondence[email protected]
&
Thys van der Molen1 Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands;2 Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
 show all
Pages 273-286 | Published online: 06 Jun 2013

Figures & data

Table 1 Patient demographics

Figure 1 Course of the mean FEV1, BORG, CCQ total and domain scores, and SGRQ total and domain scores.

Abbreviations: FEV1, forced expiratory flow in one second; CCQ, Clinical COPD Questionnaire; COPD, chronic obstructive pulmonary disease; SGRQ, St George’s Respiratory Questionnaire.
Figure 1 Course of the mean FEV1, BORG, CCQ total and domain scores, and SGRQ total and domain scores.

Figure 2 Mean change in minimal clinically important differences of FEV1, BORG, CCQ, and SGRQ.

Note: Error bars represent the standard error of measurement.
Abbreviations: FEV1, forced expiratory flow in one second; CCQ, Clinical COPD Questionnaire; COPD, chronic obstructive pulmonary disease; SGRQ, St George’s Respiratory Questionnaire; n, number of patients completed the measurement; MCID, minimal clinically important difference.
Figure 2 Mean change in minimal clinically important differences of FEV1, BORG, CCQ, and SGRQ.

Table 2 Responsiveness of patient-reported outcomes and lung function on day 7

Figure 3 Course of Clinical COPD Questionnaire total scores in hospitalized patients and outpatients during recovery from an exacerbation of COPD.

Notes: Time points −2 and −1 represent run-in visits.Reprinted with permission from Kocks JWH, Kerstjens HAM, van den Berg JWK, van der Molen T. The course of health status during an exacerbation of COPD in hospitalized patients versus outpatient treated patients. Prim Care Respir J. 2010;19:A8–A9.Citation29
Abbreviation: COPD, chronic obstructive pulmonary disease.
Figure 3 Course of Clinical COPD Questionnaire total scores in hospitalized patients and outpatients during recovery from an exacerbation of COPD.

Table 3 Cox regression models describing prediction of treatment failure

Figure 4 Cox survival curve for re-exacerbation within a year, beginning at six weeks after hospitalization.

Notes: Groups are divided by CCQ score tertiles (CCQ < 1.8; 1.8–2.6; > 2.6).
Abbreviations: CCQ, Clinical COPD Questionnaire; COPD, chronic obstructive pulmonary disease.
Figure 4 Cox survival curve for re-exacerbation within a year, beginning at six weeks after hospitalization.

Figure 5 Proportion of patients alive after hospitalization for an exacerbation of COPD (CCQ score < 1.8; 1.8–2.6;>2.6).

Abbreviations: CCQ, Clinical COPD Questionnaire; COPD, chronic obstructive pulmonary disease.
Figure 5 Proportion of patients alive after hospitalization for an exacerbation of COPD (CCQ score < 1.8; 1.8–2.6;>2.6).

Table A1 Cox regression models: treatment failure

Table A2 Cox regression models: time to exacerbation

Table A3 Cox regression models: mortality

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