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ORIGINAL RESEARCH

Association Between Serum Klotho and Chronic Obstructive Pulmonary Disease in US Middle-Aged and Older Individuals: A Cross-Sectional Study from NHANES 2013–2016

ORCID Icon, ORCID Icon, , , &
Pages 543-553 | Received 26 Nov 2023, Accepted 20 Feb 2024, Published online: 25 Feb 2024

Figures & data

Figure 1 Flowchart of participants selection.

Abbreviations: NHANES, National Health and Nutrition Examination Survey; BMI, body mass index.
Figure 1 Flowchart of participants selection.

Table 1 Baseline Characteristics of Participants Base on the Quartiles of Serum Klotho

Table 2 Associations Between Serum Klotho and COPD in the Multiple Regression Model

Figure 2 Associations between ln-transformed serum Klotho and chronic obstructive pulmonary disease in different subgroups. Except for the stratification component itself, each stratification factor was adjusted for sex, age, race and ethnicity, educational level, marital status, physical activity, smoking status, alcohol drinking status, PIR, BMI, albumin, uric acid, HDL, TC, BUN, Scr, eGFR, hypertension, diabetes mellitus, cancer, CVD, CKD.

Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval; PIR, Ratio of family income to poverty; BMI, body mass index; HDL, high-density lipoprotein; TC, Total cholesterol; BUN, blood urea nitrogen; Scr, serum creanine; eGFR, estimated glomerular filtration rate; CVD, cardiovascular disease; CKD, chronic kidney disease.
Figure 2 Associations between ln-transformed serum Klotho and chronic obstructive pulmonary disease in different subgroups. Except for the stratification component itself, each stratification factor was adjusted for sex, age, race and ethnicity, educational level, marital status, physical activity, smoking status, alcohol drinking status, PIR, BMI, albumin, uric acid, HDL, TC, BUN, Scr, eGFR, hypertension, diabetes mellitus, cancer, CVD, CKD.