Figures & data
Table 1 Study characteristics of included trials that provide data on the total number of exacerbations and/or the mean annual rate of exacerbations
Figure 2 Diagram displaying the network of eight arms involved in the Bayesian analyses.
Abbreviations: BDP, beclomethasone dipropionate; BUD, budesonide; FF, fluticasone furoate; FM, formoterol; FP, fluticasone propionate; ICS, inhaled corticosteroids; LABA, long-acting beta agonists; MF, mometasone furoate; PLB, placebo; SAL, salmeterol; VI, vilanterol.
![Figure 2 Diagram displaying the network of eight arms involved in the Bayesian analyses.](/cms/asset/6a1640c7-bde1-4fa7-abe2-fa2e95a50d99/dcop_a_48492_f0002_b.jpg)
Figure 3 Pooled effect estimate on moderate-to-severe exacerbations for all combined inhalers versus placebo.
Abbreviations: BDP, beclomethasone dipropionate; BUD, budesonide; FF, fluticasone furoate; FM, formoterol; FP, fluticasone propionate; MF, mometasone furoate; SAL, salmeterol; VI, vilanterol.
![Figure 3 Pooled effect estimate on moderate-to-severe exacerbations for all combined inhalers versus placebo.Abbreviations: BDP, beclomethasone dipropionate; BUD, budesonide; FF, fluticasone furoate; FM, formoterol; FP, fluticasone propionate; MF, mometasone furoate; SAL, salmeterol; VI, vilanterol.](/cms/asset/57f1821f-1b37-4f89-97c5-e6d9bd8214e7/dcop_a_48492_f0003_b.jpg)
Figure 4 Pooled effect estimate on moderate-to-severe exacerbations for all combined inhalers versus long acting beta-agonist.
![Figure 4 Pooled effect estimate on moderate-to-severe exacerbations for all combined inhalers versus long acting beta-agonist.](/cms/asset/31c9df9a-7037-44e0-aa1e-8ba29a6874a6/dcop_a_48492_f0004_b.jpg)
Figure 5 Pooled effect estimate on severe exacerbations for all combined inhalers versus placebo.
Abbreviations: BDP, beclomethasone dipropionate; BUD, budesonide; FF, fluticasone furoate; FM, formoterol; FP, fluticasone propionate; MF, mometasone furoate; SAL, salmeterol; VI, vilanterol.
![Figure 5 Pooled effect estimate on severe exacerbations for all combined inhalers versus placebo.Abbreviations: BDP, beclomethasone dipropionate; BUD, budesonide; FF, fluticasone furoate; FM, formoterol; FP, fluticasone propionate; MF, mometasone furoate; SAL, salmeterol; VI, vilanterol.](/cms/asset/06967c8e-cf55-44b4-bc0c-e22579738ba8/dcop_a_48492_f0005_b.jpg)
Figure 6 Pooled effect estimate on severe exacerbations for all combined inhalers versus long acting beta-agonist.
![Figure 6 Pooled effect estimate on severe exacerbations for all combined inhalers versus long acting beta-agonist.](/cms/asset/235afa9f-609e-40bf-a400-d1e97cd4f6de/dcop_a_48492_f0006_b.jpg)
Table S1 Definitions of COPD exacerbations in the included trials