The clinical use of regenerative therapy in COPD

Figures & data

Table 1 The most important studies regarding the use of stem cells in chronic obstructive pulmonary disease

Clinical trial	Authors	Year
Lung regeneration and translational implications of the post-pneumonectomy model	Thane K, Ingenito EP, Hoffman AM^Citation16	2014
Engineered whole organs and complex tissues	Badylak SF, Weiss DJ, Caplan A, Macchiarini P^Citation27	2012
Repopulation of a human alveolar matrix by adult rat type 2 pneumocytes in vitro; a novel system for type 2 pneumocyte culture	Lwebuga-Mukasa JS, Ingbar DH, Madri JA^Citation30	1986
Autologous transplantation of adipose tissue-derived stromal cells ameliorates pulmonary emphysema	Shigemura N, Okumura M, Mizuno S, Imanishi Y, Nakamura T, Sawa Y^Citation42	2006
Adipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smoking	Schweitzer KS, Johnstone BH, Garrison J, et al^Citation48	2011
Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema	Ribeiro-Paes JT, Bilaqui A, Greco OT, et al^Citation59	2011
A placebo-controlled, randomized trial of mesenchymal stem cells in chronic obstructive pulmonary disease	Weiss DJ, Casaburi R, Flannery R, LeRoux-Williams M, Tashkin DP^Citation68	2013

ThaneKIngenitoEPHoffmanAMLung regeneration and translational implications of the postpneumonectomy modelTransl Res2014163436337624316173

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BadylakSFWeissDJCaplanAMacchiariniPEngineered whole organs and complex tissuesLancet2012379981994395222405797

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Lwebuga-MukasaJSIngbarDHMadriJARepopulation of a human alveolar matrix by adult rat type II pneumocytes in vitro. A novel system for type II pneumocyte cultureExp Cell Res198616224234353510880

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ShigemuraNOkumuraMMizunoSImanishiYNakamuraTSawaYAutologous transplantation of adipose tissue-derived stromal cells ameliorates pulmonary emphysemaAm J Transplant2006611259260017049053

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SchweitzerKSJohnstoneBHGarrisonJAdipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smokingAm J Respir Crit Care Med2011183221522520709815

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Ribeiro-PaesJTBilaquiAGrecoOTUnicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysemaInt J Chron Obstruct Pulmon Dis20116637121311694

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WeissDJCasaburiRFlanneryRLeRoux-WilliamsMTashkinDPA placebo-controlled, randomized trial of mesenchymal stem cells in COPDChest201314361590159823172272

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