Figures & data
Table 1 Overview of Phase II, Phase III, and long-term trials of aclidinium in COPD
Figure 1 Study designs for the two pivotal Phase III studies of aclidinium BID: (A) ACCORD COPD I,Citation31 and (B) ATTAIN.Citation32
![Figure 1 Study designs for the two pivotal Phase III studies of aclidinium BID: (A) ACCORD COPD I,Citation31 and (B) ATTAIN.Citation32](/cms/asset/3a58631a-8974-48d6-bb07-7bdacfa6c3a2/dcop_a_76520_f0001_b.jpg)
Figure 2 Change from baseline in (A) trough FEV1 and (B) peak FEV1 at Week 24 in ACCORD COPD I study.
Notes: *P<0.001 vs placebo; †P<0.05, ‡P<0.01 vs aclidinium 200 μg. From Kerwin EM, D’Urzo AD, Gelb AF, et al. COPD 2012;9(2):90–101. Copyright © 2012, Informa Healthcare. Reproduced with permission of Informa Healthcare.Citation31
Abbreviations: ACCORD, AClidinium in Chronic Obstructive Respiratory Disease I; FEV1, forced expiratory volume in 1 second; LS, least squares; SE, standard error.
![Figure 2 Change from baseline in (A) trough FEV1 and (B) peak FEV1 at Week 24 in ACCORD COPD I study.Notes: *P<0.001 vs placebo; †P<0.05, ‡P<0.01 vs aclidinium 200 μg. From Kerwin EM, D’Urzo AD, Gelb AF, et al. COPD 2012;9(2):90–101. Copyright © 2012, Informa Healthcare. Reproduced with permission of Informa Healthcare.Citation31Abbreviations: ACCORD, AClidinium in Chronic Obstructive Respiratory Disease I; FEV1, forced expiratory volume in 1 second; LS, least squares; SE, standard error.](/cms/asset/82e10b2d-3659-4b8c-910f-8e6bb0a2f8c0/dcop_a_76520_f0002_b.jpg)
Figure 3 Change from baseline in (A) trough FEV1 and (B) peak FEV1 at Week 24 in ATTAIN study.
Abbreviations: ATTAIN, Aclidinium To Treat Airway obstruction In COPD patieNts; BID, twice daily; FEV1, forced expiratory volume in 1 second.
![Figure 3 Change from baseline in (A) trough FEV1 and (B) peak FEV1 at Week 24 in ATTAIN study.](/cms/asset/295ebaf9-45b7-4f3f-ad3c-810e08aa9799/dcop_a_76520_f0003_b.jpg)
Figure 4 Least squares mean (standard error) change from baseline in SGRQ total score in patients on continuous aclidinium in 1-year extension study of ACCORD COPD I.
Abbreviations: ACCORD, AClidinium in Chronic Obstructive Respiratory Disease I; SGRQ, St George’s Respiratory Questionnaire.
![Figure 4 Least squares mean (standard error) change from baseline in SGRQ total score in patients on continuous aclidinium in 1-year extension study of ACCORD COPD I.](/cms/asset/64f7dcb2-7c61-4fc8-8896-53a59c338cd3/dcop_a_76520_f0004_b.jpg)
Figure 5 Percent change from baseline in frequency of night-time COPD symptoms at Week 12 in the ACCORD COPD I study.
Note: †P≤0.0023 vs placebo.
Abbreviations: ACCORD, AClidinium in Chronic Obstructive Respiratory Disease I; BID, twice daily.
![Figure 5 Percent change from baseline in frequency of night-time COPD symptoms at Week 12 in the ACCORD COPD I study.Note: †P≤0.0023 vs placebo.Abbreviations: ACCORD, AClidinium in Chronic Obstructive Respiratory Disease I; BID, twice daily.](/cms/asset/2ea00553-9375-44de-b24f-c8eef6176af9/dcop_a_76520_f0005_b.jpg)
Figure 6 Percent change from baseline in severity and impact of early morning symptoms at Week 12 in the ACCORD COPD I study.
Notes: †P=0.0009, ‡P=0.0002.
Abbreviations: ACCORD, AClidinium in Chronic Obstructive Respiratory Disease I; BID, twice daily.
![Figure 6 Percent change from baseline in severity and impact of early morning symptoms at Week 12 in the ACCORD COPD I study.Notes: †P=0.0009, ‡P=0.0002.Abbreviations: ACCORD, AClidinium in Chronic Obstructive Respiratory Disease I; BID, twice daily.](/cms/asset/e70d84b9-6166-49aa-936f-4dc072dbd848/dcop_a_76520_f0006_b.jpg)
Figure 7 Percent change from baseline in daily COPD symptoms as measured by EXACT-RS scores at Week 24 in the ATTAIN study.
Abbreviations: ATTAIN, Aclidinium to Treat Airway Obstruction in COPD Patients; BID, twice daily; EXACT-RS, EXAcerbations of Chronic pulmonary disease Tool-Respiratory Systems.
![Figure 7 Percent change from baseline in daily COPD symptoms as measured by EXACT-RS scores at Week 24 in the ATTAIN study.](/cms/asset/d8cb9306-3b03-4f85-810c-54a018785148/dcop_a_76520_f0007_b.jpg)