Influence of pulmonary emphysema on COPD assessment test-oriented categorization in GOLD document

Figures & data

Figure 1 Flow chart for study participants.

Abbreviation: GOLD, Global initiative for chronic Obstructive Lung Disease.

Table 1 Patient baseline clinical characteristics

	GOLD staging				Total population (N=200)
	I (N=40)	II (N=107)	III (N=40)	IV (N=13)
Age, years	68.9±7.2	68.7±7.8	73.6±7.9	70.5±6.1	69.8±7.9
Smoking, pack-years	47.3±30.2	49.0±37.6	55.3±33.4	77.2±36.3	51.8±36.0
BMI, kg/m^2	23.2±2.19	23.2±3.53	22.9±2.95	20.4±3.52	22.9±3.26
Male sex, %	87.5	82.2	95.0	100	87.0
Current smokers, %	22.5	20.6	17.5	15.4	20.0
CAT score	6.8±4.3	8.7±6.6	10.9±6.7	21.8±5.9	9.6±7.1
Frequent exacerbator, %	2.5	5.6	17.5	61.5	11.0
FEV1 L	2.46±0.27	1.77±0.40	1.12±0.25	0.85±0.13	1.72±0.59
FEV1 (%predicted), %	89.4±7.63	66.4±12.1	42.5±5.10	30.6±7.34	63.9± 19.8
FVC, L	3.83±0.47	3.03±0.61	2.45±0.69	2.45±0.40	3.04±0.75
FEV1/FVC, %	64.6±5.22	58.0±7.98	47.2±10.2	33.6±6.83	55.6±11.3
DLCO/VA (%predicted), %	80.7± 16.4	76.9±19.5	74.2±21.0	42.0±22.5	74.7±21.5
RV/TLC, %	34.1 ±4.33	41.3±4.59	48.5±5.08	52.1 ±5.31	42.2±6.82
LAV, %	1.26± 1.84	4.75±6.14	7.80±9.66	24.2±14.2	6.21 ±8.83

Notes: Plus-minus values are mean ± SD. Other values are number (%).

Abbreviations: BMI, body mass index; CAT, chronic obstructive pulmonary disease assessment test; DL_CO/VA (%predicted), percentage of the diffusing capacity for carbon monoxide per liter of lung volume predicted value; FEV₁, forced expiratory volume in 1 second; FEV₁ (%predicted), percentage of the FEV₁ predicted value; FVC, forced vital capacity; FEV₁/FVC, ratio of FEV₁/FVC; GOLD, Global initiative for chronic Obstructive Lung Disease; LAV, low attenuation volume; RV/TLC, ratio of residual volume to total lung capacity; SD, standard deviation.

Figure 2 Correlations between CAT scores and PFT parameters and MDCT parameters.

Notes: (A) Correlation between CAT score and FEV₁ (%predicted). (B) Correlation between CAT score and DL_CO/VA (%predicted). (C) Correlation between CAT score and LAV%.
Abbreviations: CAT, chronic obstructive pulmonary disease assessment test; DL_CO/VA (%predicted), percentage of the diffusing capacity for carbon monoxide per liter of lung volume predicted value; FEV₁ (%predicted), percentage of the FEV₁ predicted value; LAV%, low attenuation volume percentage; FEV₁, forced expiratory volume in 1 second; PFT, pulmonary function test; MDCT, multidetector computed tomography.

Table 2 Patient clinical characteristics in each COPD category

Notes: Values are mean ± SD. Other values are number (%). *P<0.05; **P<0.01.

Abbreviations: BMI, body mass index; COPD, chronic obstructive pulmonary disease; DL_CO/VA (%predicted), percentage of the diffusing capacity for carbon monoxide per liter of lung volume predicted value; FEV₁ (%predicted), percentage of the FEV₁ predicted value; FVC, forced vital capacity; LAV, low attenuation volume; RV, residual volume; SD, standard deviation; TLC, total lung capacity; RV/TLC, ratio of residual volume to total lung capacity; VC, vital capacity; FEV₁, forced expiratory volume in 1 second.