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Original Research

Biomarker-based detection of asthma–COPD overlap syndrome in COPD populations

, , , , , , , , & show all
Pages 2169-2176 | Published online: 09 Oct 2015

Figures & data

Table 1 Characteristics of the subjects

Table 2 Comparison of clinical characteristics between high and low groups in FENO and IgE

Figure 1 Histogram of FENO values in the subjects.

Notes: All 331 COPD patients were measured for FENO before their enrollment. The frequencies of patients without ICS are indicated by white bars, and ICS users are indicated by gray bars. The number of patients with FENO over 25 ppb were 112 (36.9%) cases; the number of patients with FENO over 35 ppb were 54 (16.3%) cases; and the number of patients with FENO over 50 ppb were 17 (5.1%) cases.
Abbreviations: COPD, chronic obstructive pulmonary disease; ICS, inhaled corticosteroids; FENO, fractional exhaled nitric oxide.
Figure 1 Histogram of FENO values in the subjects.

Figure 2 Histogram of total IgE values in the subjects.

Notes: A total of 230 (69.8%) of the 331 COPD patients were measured for total IgE before the enrollment. When the cutoff value of IgE was set at 173 IU/mL, there were 82 (35.7%) patients with a high level of total IgE out of 230 COPD patients.
Abbreviation: IgE, immunoglobulin E.
Figure 2 Histogram of total IgE values in the subjects.

Figure 3 Number of patients when estimated by both FENO and IgE.

Notes: Patients were divided into subgroups by FENO and IgE as asthma-like inflammatory and atopic biomarkers, respectively. The dark gray bar represents the high-FENO/high-IgE group; the light gray bar represents either the high-FENO/low-IgE or low-FENO/high-IgE group; and the white bar represents the low-FENO/low-IgE group.
Abbreviations: FENO, fractional exhaled nitric oxide; IgE, immunoglobulin E.
Figure 3 Number of patients when estimated by both FENO and IgE.