Anti-Xa Inhibitor-Induced Hemorrhagic Pruritic Rash: A Case Report on Possible Cross-Reactivity Between Apixaban and Rivaroxaban

Figures & data

Table 1 Naranjo Adverse Drug Reaction Probability Scale for Apixaban-Induced Rash.

Assessment Questions	Yes	No	Do Not Know
1. Are there previous conclusive reports on this reaction?	+1	0	0
2. Did the adverse drug reaction appear after the suspected drug was administered?	+2	−1	0
3. Did the adverse drug reaction improve when the drug was discontinued?	+1	0	0
4. Did the adverse drug reaction reappear when the drug was readministered?	+1	0	0
5. Are there alternative causes for this adverse drug reaction?	−1	+2	0
6. Did the reaction reappear when a placebo was given?	−1	+1	0
7. Was the drug detected in blood or other fluids in concentrations known to be toxic?	+1	0	0
8. Was the reaction more severe when the dose was increased or less severe when the dose was decreased?	+1	0	0
9. Did the patient have a similar reaction to the same or similar drugs in any previous exposure?	+1	0	0
10. Was the adverse drug reaction confirmed by any objective evidence?	+1	0	0
Total score	7 = Probable

Notes: Bolded text = score assigned to each question. Reproduced from Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30(2):239–245. © 1981 American Society for Clinical Pharmacology and Therapeutics.¹¹

NaranjoCA, BustoU, SellersEM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30(2):239–245. doi:10.1038/clpt.1981.1547249508

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