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Review

Differential characteristics of incobotulinumtoxinA and its use in the management of glabellar frown lines

Pages 39-52 | Published online: 12 Mar 2013

Figures & data

Figure 1 Muscles involved in glabellar frown lines. Reproduced with permission from Merz Pharmaceuticals GmbH.

Figure 1 Muscles involved in glabellar frown lines. Reproduced with permission from Merz Pharmaceuticals GmbH.

Table 1 Use of botulinum neurotoxin type A products for the treatment of glabellar frown lines: manufacturer’s recommendationsCitation24,Citation27,Citation37

Figure 2 Injection sites for treatment of glabellar frown lines. Reproduced with permission from Merz Pharmaceuticals GmbH.

Figure 2 Injection sites for treatment of glabellar frown lines. Reproduced with permission from Merz Pharmaceuticals GmbH.

Table 2 Summary of characteristics of botulinum neurotoxin type A products used in the treatment of glabellar frown linesCitation24,Citation27,Citation37,Citation57,Citation60,Citation61,Citation91

Figure 3 Amount of clostridial protein and neurotoxin per 100 U of incobotulinumtoxinA, onabotulinumtoxinA, and abobotulinumtoxinA.Citation37,Citation61,Citation72

Figure 3 Amount of clostridial protein and neurotoxin per 100 U of incobotulinumtoxinA, onabotulinumtoxinA, and abobotulinumtoxinA.Citation37,Citation61,Citation72

Figure 4 Subject assessment of response with 20 U, using a 4-point scale where a responder was defined as a subject with at least a 1-point improvement compared with baseline at Day 30 from two Phase iii, placebo-controlled trials: (A) Carruthers et al,Citation42 full-analysis set; and (B) Hanke et al,Citation43 full-analysis set, observed cases.

Figure 4 Subject assessment of response with 20 U, using a 4-point scale where a responder was defined as a subject with at least a 1-point improvement compared with baseline at Day 30 from two Phase iii, placebo-controlled trials: (A) Carruthers et al,Citation42 full-analysis set; and (B) Hanke et al,Citation43 full-analysis set, observed cases.