Evaluating the effects of dexmedetomidine compared to propofol as adjunctive therapy in patients with alcohol withdrawal

Figures & data

Figure 1 Patient population.

Abbreviations: BZD, benzodiazepine; AP, antipsychotic; AW, alcohol withdrawal; DEX, dexmedetomidine; PROP, propofol.

Figure 2 Study timeline and results.

Table 1 Equipotent doses of various benzodiazepines

Benzodiazepine	Equipotent dose
Lorazepam – IV/PO	1 mg
Diazepam – IV/PO	5 mg
Chlordiazepoxide – PO	25 mg

Abbreviations: IV, intravenous; PO, orally.

Figure 3 (A) Benzodiazepine reduction and (B) haloperidol reduction.

Abbreviation: CI, confidence interval.

Table 2 Adverse events

	Bradycardia (HR less than 60 bpm)	Hypotension (SBP less than90 mmHg)	Discontinued due to ADR
Dexmedetomidine (n=34)	6 (17.6%)	6 (17.6%)	1 (2.8%)
Propofol (n=7)	0 (0%)	2 (28.5%)	0 (0%)

Abbreviations: HR, heart rate; SBP, systolic blood pressure; ADR, adverse drug reaction; bpm, beats per minute.